Association of echocardiographic left ventricular structure with the ACE D/I polymorphism: A meta-analysis

Yu Jin, Tatiana Kuznetsova, Lutgarde Thijs, Tom Richart, Katarzyna Stolarz-Skrzypek, Yanping Liu, Robert Fagard, Paolo Manunta, Giuseppe Bianchi, Jan A. Staessen

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Introduction: In a previous meta-analysis, we derived pooled estimates for the association of left ventricular mass (LVM) and hypertrophy (LVH), as diagnosed by electrocardiography or echocardiography, with the ACE D/I polymorphism. We updated this meta-analysis until May 2009 only considering echocardiographic phenotypes. Methods: We computed pooled estimates from a random-effects model. Results: Across 38 studies, both DD homozygotes (n = 2440) and DI heterozygotes ( n = 4310) had higher (p ≤ 0.002) LVM or LVM index than II homozygotes (n = 2229). Across 21 studies with available data, this was due to increased mean wall thickness (MWT) with no difference in left ventricular internal diameter (LVID). Standardised differences (DD versus II) were 0.39 (p <0.001) for LVM, 0.34 (p = 0.009) for MWT, and 0.066 (p = 0.26) for LVID. Across 16 studies (4894 participants), the pooled odds ratios of LVH (versus II homozygotes) were 1.11 (p = 0.29) and 1.02 (p = 0.88) for the DD and DI genotypes, respectively. Sensitivity analyses were confirmatory. Conclusions: Our meta-analysis supports the hypothesis that the enhanced ACE activity associated with the D allele is associated with higher LV mass. Smaller sample size might explain the lack of significant association with LVH.

Original languageEnglish
Pages (from-to)243-253
Number of pages11
JournalJRAAS - Journal of the Renin-Angiotensin-Aldosterone System
Volume12
Issue number3
DOIs
Publication statusPublished - Sep 2011

Fingerprint

Homozygote
Meta-Analysis
Hypertrophy
Left Ventricular Hypertrophy
Heterozygote
Sample Size
Echocardiography
Electrocardiography
Alleles
Odds Ratio
Genotype
Phenotype

Keywords

  • ACE
  • echocardiography
  • left ventricular geometry
  • left ventricular mass
  • meta-analysis

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology

Cite this

Association of echocardiographic left ventricular structure with the ACE D/I polymorphism : A meta-analysis. / Jin, Yu; Kuznetsova, Tatiana; Thijs, Lutgarde; Richart, Tom; Stolarz-Skrzypek, Katarzyna; Liu, Yanping; Fagard, Robert; Manunta, Paolo; Bianchi, Giuseppe; Staessen, Jan A.

In: JRAAS - Journal of the Renin-Angiotensin-Aldosterone System, Vol. 12, No. 3, 09.2011, p. 243-253.

Research output: Contribution to journalArticle

Jin, Y, Kuznetsova, T, Thijs, L, Richart, T, Stolarz-Skrzypek, K, Liu, Y, Fagard, R, Manunta, P, Bianchi, G & Staessen, JA 2011, 'Association of echocardiographic left ventricular structure with the ACE D/I polymorphism: A meta-analysis', JRAAS - Journal of the Renin-Angiotensin-Aldosterone System, vol. 12, no. 3, pp. 243-253. https://doi.org/10.1177/1470320310387178
Jin, Yu ; Kuznetsova, Tatiana ; Thijs, Lutgarde ; Richart, Tom ; Stolarz-Skrzypek, Katarzyna ; Liu, Yanping ; Fagard, Robert ; Manunta, Paolo ; Bianchi, Giuseppe ; Staessen, Jan A. / Association of echocardiographic left ventricular structure with the ACE D/I polymorphism : A meta-analysis. In: JRAAS - Journal of the Renin-Angiotensin-Aldosterone System. 2011 ; Vol. 12, No. 3. pp. 243-253.
@article{7e2bdd8fa0c2403f82dbbee277fe8e5a,
title = "Association of echocardiographic left ventricular structure with the ACE D/I polymorphism: A meta-analysis",
abstract = "Introduction: In a previous meta-analysis, we derived pooled estimates for the association of left ventricular mass (LVM) and hypertrophy (LVH), as diagnosed by electrocardiography or echocardiography, with the ACE D/I polymorphism. We updated this meta-analysis until May 2009 only considering echocardiographic phenotypes. Methods: We computed pooled estimates from a random-effects model. Results: Across 38 studies, both DD homozygotes (n = 2440) and DI heterozygotes ( n = 4310) had higher (p ≤ 0.002) LVM or LVM index than II homozygotes (n = 2229). Across 21 studies with available data, this was due to increased mean wall thickness (MWT) with no difference in left ventricular internal diameter (LVID). Standardised differences (DD versus II) were 0.39 (p <0.001) for LVM, 0.34 (p = 0.009) for MWT, and 0.066 (p = 0.26) for LVID. Across 16 studies (4894 participants), the pooled odds ratios of LVH (versus II homozygotes) were 1.11 (p = 0.29) and 1.02 (p = 0.88) for the DD and DI genotypes, respectively. Sensitivity analyses were confirmatory. Conclusions: Our meta-analysis supports the hypothesis that the enhanced ACE activity associated with the D allele is associated with higher LV mass. Smaller sample size might explain the lack of significant association with LVH.",
keywords = "ACE, echocardiography, left ventricular geometry, left ventricular mass, meta-analysis",
author = "Yu Jin and Tatiana Kuznetsova and Lutgarde Thijs and Tom Richart and Katarzyna Stolarz-Skrzypek and Yanping Liu and Robert Fagard and Paolo Manunta and Giuseppe Bianchi and Staessen, {Jan A.}",
year = "2011",
month = "9",
doi = "10.1177/1470320310387178",
language = "English",
volume = "12",
pages = "243--253",
journal = "JRAAS - Journal of the Renin-Angiotensin-Aldosterone System",
issn = "1470-3203",
publisher = "SAGE Publications Ltd",
number = "3",

}

TY - JOUR

T1 - Association of echocardiographic left ventricular structure with the ACE D/I polymorphism

T2 - A meta-analysis

AU - Jin, Yu

AU - Kuznetsova, Tatiana

AU - Thijs, Lutgarde

AU - Richart, Tom

AU - Stolarz-Skrzypek, Katarzyna

AU - Liu, Yanping

AU - Fagard, Robert

AU - Manunta, Paolo

AU - Bianchi, Giuseppe

AU - Staessen, Jan A.

PY - 2011/9

Y1 - 2011/9

N2 - Introduction: In a previous meta-analysis, we derived pooled estimates for the association of left ventricular mass (LVM) and hypertrophy (LVH), as diagnosed by electrocardiography or echocardiography, with the ACE D/I polymorphism. We updated this meta-analysis until May 2009 only considering echocardiographic phenotypes. Methods: We computed pooled estimates from a random-effects model. Results: Across 38 studies, both DD homozygotes (n = 2440) and DI heterozygotes ( n = 4310) had higher (p ≤ 0.002) LVM or LVM index than II homozygotes (n = 2229). Across 21 studies with available data, this was due to increased mean wall thickness (MWT) with no difference in left ventricular internal diameter (LVID). Standardised differences (DD versus II) were 0.39 (p <0.001) for LVM, 0.34 (p = 0.009) for MWT, and 0.066 (p = 0.26) for LVID. Across 16 studies (4894 participants), the pooled odds ratios of LVH (versus II homozygotes) were 1.11 (p = 0.29) and 1.02 (p = 0.88) for the DD and DI genotypes, respectively. Sensitivity analyses were confirmatory. Conclusions: Our meta-analysis supports the hypothesis that the enhanced ACE activity associated with the D allele is associated with higher LV mass. Smaller sample size might explain the lack of significant association with LVH.

AB - Introduction: In a previous meta-analysis, we derived pooled estimates for the association of left ventricular mass (LVM) and hypertrophy (LVH), as diagnosed by electrocardiography or echocardiography, with the ACE D/I polymorphism. We updated this meta-analysis until May 2009 only considering echocardiographic phenotypes. Methods: We computed pooled estimates from a random-effects model. Results: Across 38 studies, both DD homozygotes (n = 2440) and DI heterozygotes ( n = 4310) had higher (p ≤ 0.002) LVM or LVM index than II homozygotes (n = 2229). Across 21 studies with available data, this was due to increased mean wall thickness (MWT) with no difference in left ventricular internal diameter (LVID). Standardised differences (DD versus II) were 0.39 (p <0.001) for LVM, 0.34 (p = 0.009) for MWT, and 0.066 (p = 0.26) for LVID. Across 16 studies (4894 participants), the pooled odds ratios of LVH (versus II homozygotes) were 1.11 (p = 0.29) and 1.02 (p = 0.88) for the DD and DI genotypes, respectively. Sensitivity analyses were confirmatory. Conclusions: Our meta-analysis supports the hypothesis that the enhanced ACE activity associated with the D allele is associated with higher LV mass. Smaller sample size might explain the lack of significant association with LVH.

KW - ACE

KW - echocardiography

KW - left ventricular geometry

KW - left ventricular mass

KW - meta-analysis

UR - http://www.scopus.com/inward/record.url?scp=80052349627&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80052349627&partnerID=8YFLogxK

U2 - 10.1177/1470320310387178

DO - 10.1177/1470320310387178

M3 - Article

C2 - 21273223

AN - SCOPUS:80052349627

VL - 12

SP - 243

EP - 253

JO - JRAAS - Journal of the Renin-Angiotensin-Aldosterone System

JF - JRAAS - Journal of the Renin-Angiotensin-Aldosterone System

SN - 1470-3203

IS - 3

ER -