Association of EEG, MRI, and regional blood flow biomarkers is predictive of prodromal alzheimer’s disease

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Thinning in the temporoparietal cortex, hippocampal atrophy, and a lower regional blood perfusion is connected with prodromal stage of Alzheimer’s disease (AD). Of note, an increase of electroencephalography (EEG) upper/low alpha frequency power ratio has also been associated with these major landmarks of prodromal AD. Methods: Clinical and neuropsychological assessment, EEG recording, and high-resolution three-dimensional magnetic resonance imaging were done in 74 grown up subjects with mild cognitive impairment. This information was gathered and has been assessed 3 years postliminary. EEG recording and perfusion single-photon emission computed tomography assessment was done in 27 subjects. Alpha3/alpha2 frequency power ratio, including cortical thickness, was figured for every subject. Contrasts in cortical thickness among the groups were assessed. Pearson’s r relationship coefficient was utilized to evaluate the quality of the relationship between cortical thinning, brain perfusion, and EEG markers. Results: The higher alpha3/alpha2 frequency power ratio group corresponded with more prominent cortical decay and a lower perfusional rate in the temporoparietal cortex. In a subsequent meetup after 3 years, these patients had AD. Conclusion: High EEG upper/low alpha power ratio was connected with cortical diminishing and lower perfusion in the temporoparietal brain area. The increase in EEG upper/low alpha frequency power ratio could be helpful in recognizing people in danger of conversion to AD dementia and this may be quality information in connection with clinical assessment.

Original languageEnglish
Pages (from-to)2779-2791
Number of pages13
JournalNeuropsychiatric Disease and Treatment
Volume11
DOIs
Publication statusPublished - Oct 27 2015

Keywords

  • Biomarkers
  • Brain rhythms
  • Electroencephalography
  • Hippocampal volume
  • Mild cognitive impairment

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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