Association of epirubicin, etoposide and cisplatin in gastric cancer. A phase II study

C. Barone, A. Cassano, A. Astone, E. Ricevuto, T. Fontana, M. R. Noviello, C. Garufi, F. Pacelli, A. Grieco

Research output: Contribution to journalArticle

Abstract

Cisplatin-based drug combinations are now currently investigated in an attempt to surpass the results obtainable by 5-FU alone or by 5-FU-containing regimens. We evaluated 29 patients with advanced and measurable gastric adenocarcinoma treated with etoposide, epirubicin and cisplatin. One patient had complete response (3±7%); 9 patients had partial response (31±17%); 5 patients (17±14%) were considered stable (S) and 14 (48±18%) were classified as progressive. The average survival time for the entire group was 11 months with 25% of the patients alive at 24 months. We feel that cisplatin-containing regimens are promising and deserve further investigations. To clearly explore the potential innovative role of these regimens randomized trials versus FAM or 5-FU alone are mandatory.

Original languageEnglish
Pages (from-to)353-355
Number of pages3
JournalOncology
Volume48
Issue number5
Publication statusPublished - 1991

Keywords

  • Chemotherapy
  • Cisplatin
  • Epirubicin
  • Etoposide
  • Gastric cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Barone, C., Cassano, A., Astone, A., Ricevuto, E., Fontana, T., Noviello, M. R., Garufi, C., Pacelli, F., & Grieco, A. (1991). Association of epirubicin, etoposide and cisplatin in gastric cancer. A phase II study. Oncology, 48(5), 353-355.