Association of factor VII levels with inflammatory parameters in hypercholesterolemic patients

Ettore Porreca, Concetta Di Febbo, Augusto Di Castelnuovo, Giovanna Baccante, Concetta Amore, Antonio Angelini, Marcello Di Nisio, Maria Benedetta Donati, Franco Cuccurullo, Licia Iacoviello

Research output: Contribution to journalArticlepeer-review

Abstract

Inflammatory markers have been demonstrated to be associated with increased risk of cardiovascular events. In this setting, C-reactive protein (CRP) was shown to add predictive value to cholesterol levels. We investigated hypercholesterolemic patients and related their inflammatory variables and their coagulation state focusing on factor VII, a coagulation protein which plays an established role in thrombogenesis. We examined the relationship between factor VII clotting activity (FVIIc), FVII antigen (FVIIAg) and activated FVII (FVIIa) levels against CRP, interleukin-6 soluble receptor (IL-6sR), P-selectin, soluble intercellular adhesion molecule-1 (ICAM-1) and transforming growth factor-β1 (TGF-β1), in fifty-eight hypercholesterolemic subjects. Patients were subjected to 6-8 weeks of lipid lowering treatment with diet or diet plus pravastatin (40 mg/day). Univariate analysis showed that FVII levels were positively associated with CRP (FVIIAg: r=0.56, P

Original languageEnglish
Pages (from-to)159-166
Number of pages8
JournalAtherosclerosis
Volume165
Issue number1
DOIs
Publication statusPublished - Nov 2002

Keywords

  • Factor VII
  • Hypercholesterolemia
  • Inflammation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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