Association of familial risk for schizophrenia with thalamic and medial prefrontal functional connectivity during attentional control

Linda A. Antonucci, Paolo Taurisano, Leonardo Fazio, Barbara Gelao, Raffaella Romano, Tiziana Quarto, Annamaria Porcelli, Marina Mancini, Annabella Di Giorgio, Grazia Caforio, Giulio Pergola, Teresa Popolizio, Alessandro Bertolino, Giuseppe Blasi

Research output: Contribution to journalArticle

Abstract

Anomalies in behavioral correlates of attentional processing and related brain activity are crucial correlates of schizophrenia and associated with familial risk for this brain disorder. However, it is not clear how brain functional connectivity during attentional processes is key for schizophrenia and linked with trait vs. state related variables. To address this issue, we investigated patterns of functional connections during attentional control in healthy siblings of patients with schizophrenia, who share with probands genetic features but not variables related to the state of the disorder. 356 controls, 55 patients with schizophrenia on stable treatment with antipsychotics and 40 healthy siblings of patients with this brain disorder underwent the Variable Attentional Control (VAC) task during fMRI. Independent Component Analysis (ICA) is allowed to identify independent components (IC) of BOLD signal recorded during task performance. Results indicated reduced connectivity strength in patients with schizophrenia as well as in their healthy siblings in left thalamus within an attentional control component and greater connectivity in right medial prefrontal cortex (PFC) within the so-called Default Mode Network (DMN) compared to healthy individuals. These results suggest a relationship between familial risk for schizophrenia and brain functional networks during attentional control, such that this biological phenotype may be considered a useful intermediate phenotype in order to link genes effects to aspects of the pathophysiology of this brain disorder.

Original languageEnglish
JournalSchizophrenia Research
DOIs
Publication statusAccepted/In press - Jun 30 2015

Keywords

  • Attentional control
  • Default mode network
  • FMRI
  • Independent component analysis
  • Schizophrenia
  • Thalamus

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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    Antonucci, L. A., Taurisano, P., Fazio, L., Gelao, B., Romano, R., Quarto, T., Porcelli, A., Mancini, M., Di Giorgio, A., Caforio, G., Pergola, G., Popolizio, T., Bertolino, A., & Blasi, G. (Accepted/In press). Association of familial risk for schizophrenia with thalamic and medial prefrontal functional connectivity during attentional control. Schizophrenia Research. https://doi.org/10.1016/j.schres.2016.03.014