Association of familial risk for schizophrenia with thalamic and medial prefrontal functional connectivity during attentional control

Linda A. Antonucci, Paolo Taurisano, Leonardo Fazio, Barbara Gelao, Raffaella Romano, Tiziana Quarto, Annamaria Porcelli, Marina Mancini, Annabella Di Giorgio, Grazia Caforio, Giulio Pergola, Teresa Popolizio, Alessandro Bertolino, Giuseppe Blasi

Research output: Contribution to journalArticle

Abstract

Anomalies in behavioral correlates of attentional processing and related brain activity are crucial correlates of schizophrenia and associated with familial risk for this brain disorder. However, it is not clear how brain functional connectivity during attentional processes is key for schizophrenia and linked with trait vs. state related variables. To address this issue, we investigated patterns of functional connections during attentional control in healthy siblings of patients with schizophrenia, who share with probands genetic features but not variables related to the state of the disorder. 356 controls, 55 patients with schizophrenia on stable treatment with antipsychotics and 40 healthy siblings of patients with this brain disorder underwent the Variable Attentional Control (VAC) task during fMRI. Independent Component Analysis (ICA) is allowed to identify independent components (IC) of BOLD signal recorded during task performance. Results indicated reduced connectivity strength in patients with schizophrenia as well as in their healthy siblings in left thalamus within an attentional control component and greater connectivity in right medial prefrontal cortex (PFC) within the so-called Default Mode Network (DMN) compared to healthy individuals. These results suggest a relationship between familial risk for schizophrenia and brain functional networks during attentional control, such that this biological phenotype may be considered a useful intermediate phenotype in order to link genes effects to aspects of the pathophysiology of this brain disorder.

Original languageEnglish
Pages (from-to)23-9
Number of pages7
JournalSchizophrenia Research
Volume173
Issue number1-2
DOIs
Publication statusPublished - 2016

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Schizophrenia
Brain Diseases
Siblings
Brain
Phenotype
Task Performance and Analysis
Prefrontal Cortex
Thalamus
Antipsychotic Agents
Magnetic Resonance Imaging
Genes
Therapeutics

Keywords

  • Adult
  • Analysis of Variance
  • Attention
  • Brain Mapping
  • Family Health
  • Female
  • Humans
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging
  • Male
  • Models, Neurological
  • Oxygen
  • Prefrontal Cortex
  • Principal Component Analysis
  • Psychiatric Status Rating Scales
  • Schizophrenia
  • Thalamus
  • Young Adult
  • Journal Article

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Association of familial risk for schizophrenia with thalamic and medial prefrontal functional connectivity during attentional control. / Antonucci, Linda A.; Taurisano, Paolo; Fazio, Leonardo; Gelao, Barbara; Romano, Raffaella; Quarto, Tiziana; Porcelli, Annamaria; Mancini, Marina; Di Giorgio, Annabella; Caforio, Grazia; Pergola, Giulio; Popolizio, Teresa; Bertolino, Alessandro; Blasi, Giuseppe.

In: Schizophrenia Research, Vol. 173, No. 1-2, 2016, p. 23-9.

Research output: Contribution to journalArticle

Antonucci, LA, Taurisano, P, Fazio, L, Gelao, B, Romano, R, Quarto, T, Porcelli, A, Mancini, M, Di Giorgio, A, Caforio, G, Pergola, G, Popolizio, T, Bertolino, A & Blasi, G 2016, 'Association of familial risk for schizophrenia with thalamic and medial prefrontal functional connectivity during attentional control', Schizophrenia Research, vol. 173, no. 1-2, pp. 23-9. https://doi.org/10.1016/j.schres.2016.03.014
Antonucci, Linda A. ; Taurisano, Paolo ; Fazio, Leonardo ; Gelao, Barbara ; Romano, Raffaella ; Quarto, Tiziana ; Porcelli, Annamaria ; Mancini, Marina ; Di Giorgio, Annabella ; Caforio, Grazia ; Pergola, Giulio ; Popolizio, Teresa ; Bertolino, Alessandro ; Blasi, Giuseppe. / Association of familial risk for schizophrenia with thalamic and medial prefrontal functional connectivity during attentional control. In: Schizophrenia Research. 2016 ; Vol. 173, No. 1-2. pp. 23-9.
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AU - Antonucci, Linda A.

AU - Taurisano, Paolo

AU - Fazio, Leonardo

AU - Gelao, Barbara

AU - Romano, Raffaella

AU - Quarto, Tiziana

AU - Porcelli, Annamaria

AU - Mancini, Marina

AU - Di Giorgio, Annabella

AU - Caforio, Grazia

AU - Pergola, Giulio

AU - Popolizio, Teresa

AU - Bertolino, Alessandro

AU - Blasi, Giuseppe

N1 - Copyright © 2016 Elsevier B.V. All rights reserved.

PY - 2016

Y1 - 2016

N2 - Anomalies in behavioral correlates of attentional processing and related brain activity are crucial correlates of schizophrenia and associated with familial risk for this brain disorder. However, it is not clear how brain functional connectivity during attentional processes is key for schizophrenia and linked with trait vs. state related variables. To address this issue, we investigated patterns of functional connections during attentional control in healthy siblings of patients with schizophrenia, who share with probands genetic features but not variables related to the state of the disorder. 356 controls, 55 patients with schizophrenia on stable treatment with antipsychotics and 40 healthy siblings of patients with this brain disorder underwent the Variable Attentional Control (VAC) task during fMRI. Independent Component Analysis (ICA) is allowed to identify independent components (IC) of BOLD signal recorded during task performance. Results indicated reduced connectivity strength in patients with schizophrenia as well as in their healthy siblings in left thalamus within an attentional control component and greater connectivity in right medial prefrontal cortex (PFC) within the so-called Default Mode Network (DMN) compared to healthy individuals. These results suggest a relationship between familial risk for schizophrenia and brain functional networks during attentional control, such that this biological phenotype may be considered a useful intermediate phenotype in order to link genes effects to aspects of the pathophysiology of this brain disorder.

AB - Anomalies in behavioral correlates of attentional processing and related brain activity are crucial correlates of schizophrenia and associated with familial risk for this brain disorder. However, it is not clear how brain functional connectivity during attentional processes is key for schizophrenia and linked with trait vs. state related variables. To address this issue, we investigated patterns of functional connections during attentional control in healthy siblings of patients with schizophrenia, who share with probands genetic features but not variables related to the state of the disorder. 356 controls, 55 patients with schizophrenia on stable treatment with antipsychotics and 40 healthy siblings of patients with this brain disorder underwent the Variable Attentional Control (VAC) task during fMRI. Independent Component Analysis (ICA) is allowed to identify independent components (IC) of BOLD signal recorded during task performance. Results indicated reduced connectivity strength in patients with schizophrenia as well as in their healthy siblings in left thalamus within an attentional control component and greater connectivity in right medial prefrontal cortex (PFC) within the so-called Default Mode Network (DMN) compared to healthy individuals. These results suggest a relationship between familial risk for schizophrenia and brain functional networks during attentional control, such that this biological phenotype may be considered a useful intermediate phenotype in order to link genes effects to aspects of the pathophysiology of this brain disorder.

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KW - Humans

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KW - Magnetic Resonance Imaging

KW - Male

KW - Models, Neurological

KW - Oxygen

KW - Prefrontal Cortex

KW - Principal Component Analysis

KW - Psychiatric Status Rating Scales

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