Association of genetic polymorphisms with survival of pancreatic ductal adenocarcinoma patients

Cosmeri Rizzato, Daniele Campa, Renata Talar-Wojnarowska, Christopher Halloran, Juozas Kupcinskas, Giovanni Butturini, Beatrice Mohelníková-Duchoňová, Cosimo Sperti, Christine Tjaden, Paula Ghaneh, Thilo Hackert, Niccola Funel, Nathalia Giese, Francesca Tavano, Raffaele Pezzilli, Mariangela Pedata, Claudio Pasquali, Maria Gazouli, Andrea Mambrini, Pavel SoučekPierluigi di Sebastiano, Gabriele Capurso, Maurizio Cantore, Martin Oliverius, Rienk Offringa, Ewa Małecka-Panas, Oliver Strobel, Aldo Scarpa, Federico Canzian

Research output: Contribution to journalArticlepeer-review

Abstract

Germline genetic variability might contribute, at least partially, to the survival of pancreatic ductal adenocarcinoma (PDAC) patients. Two recently performed genome-wide association studies (GWAS) on PDAC overall survival (OS) suggested (P < 10-5) the association between 30 genomic regions and PDAC OS. With the aim to highlight the true associations within these regions, we analyzed 44 single-nucleotide polymorphisms (SNPs) in the 30 candidate regions in 1722 PDAC patients within the PANcreatic Disease ReseArch (PANDoRA) consortium. We observed statistically significant associations for five of the selected regions. One association in the CTNNA2 gene on chromosome 2p12 [rs1567532, hazard ratio (HR) = 1.75, 95% confidence interval (CI) 1.19-2.58, P = 0.005 for homozygotes for the minor allele] and one in the last intron of the RUNX2 gene on chromosome 6p21 (rs12209785, HR = 0.88, 95% CI 0.80-0.98, P = 0.014 for heterozygotes) are of particular relevance. These loci do not coincide with those that showed the strongest associations in the previous GWAS. In silico analysis strongly suggested a possible mechanistic link between these two SNPs and pancreatic cancer survival. Functional studies are warranted to confirm the link between these genes (or other genes mapping in those regions) and PDAC prognosis in order to understand whether these variants may have the potential to impact treatment decisions and design of clinical trials.

Original languageEnglish
Article numberbgw080
Pages (from-to)957-964
Number of pages8
JournalCarcinogenesis
Volume37
Issue number10
DOIs
Publication statusPublished - Oct 1 2016

ASJC Scopus subject areas

  • Cancer Research

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