Association of genetic variants in the 3′UTR of HLA-G with Recurrent Pregnancy Loss

Giada Amodio, Valentina Canti, Luana Maggio, Susanna Rosa, Maria Teresa Castiglioni, Patrizia Rovere-Querini, Silvia Gregori

Research output: Contribution to journalArticlepeer-review


Human Leukocyte Antigen (HLA)-G is involved in reprogramming immune responses at fetal-maternal interface during pregnancy. We evaluated the genetic diversity of the 3′ Un-Translated Region (UTR) of HLA-G, previously associated with HLA-G mRNA post-transcriptional regulation, in women with unexplained Recurrent Pregnancy Loss (RPL), with 2 pregnancy losses (RPL-2, n = 28), or 3 or more pregnancy losses (RPL-3, n = 24), and in 30 women with a history of successful pregnancy. Results showed in RPL-2, but not in RPL-3, women compared to controls: i) higher frequency of the 14 bp Ins allele, in single and in double copy; ii) significantly lower frequency of DelG/X genotype, iii) reduced frequency of the UTR-2, and UTR-3 haplotypes; iv) higher frequencies of the UTR-5, UTR-7, and UTR-8 haplotypes. This pilot study supports the relevance of performing 3′UTR HLA-G genetic screening, not limited to a specific polymorphism, but considering the extended haplotypes, as a possible predictor of pregnancy outcome.

Original languageEnglish
Pages (from-to)886-891
Number of pages6
JournalHuman Immunology
Issue number10
Publication statusPublished - Oct 1 2016


  • 3′UTR polymorphisms of HLA-G
  • HLA-G
  • Unexplained Recurrent Pregnancy Loss (RPL)

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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