Association of habitual dietary resveratrol exposure with the development of frailty in older age: The Invecchiare in Chianti study1,2

Montserrat Rabassa, Raul Zamora-Ros, Mireia Urpi-Sarda, Stefania Bandinelli, Luigi Ferrucci, Cristina Andres-Lacueva, Antonio Cherubini

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: Resveratrol may play a protective role against the frailty syndrome (FS) because of its antioxidant and anti-inflammatory properties. Objective: We prospectively evaluated the association between habitual dietary resveratrol exposure and the development of FS after 3-, 6-, and 9-y follow-up periods in a community-dwelling older population. Design: We conducted a longitudinal analysis with the use of data from 769 participants aged $65 y from the Invecchiare in Chianti (Aging in Chianti) study. Total dietary resveratrol (TDR) intake was estimated at baseline with the use of a validated food-frequency questionnaire, which was developed to assess participants' usual food intakes over the previous year, and an ad hoc resveratrol database. Total urinary resveratrol (TUR) was analyzed with the use of liquid chromatography-tandem mass spectrometry with a previous solid-phase extraction at baseline. The combination of both measures [total dietary resveratrol plus total urinary resveratrol (TDR +TUR)] was computed with the use of the Howe's method. FS was assessed at baseline and at 3-, 6-, and 9-y of follow-up and was defined as the presence of $3 of the following 5 criteria: shrinking, exhaustion, sedentariness, slowness, and weakness. Results: TDR+TUR concentrations were inversely associated with FS risk over 3-y of follow-up (OR for comparison of extreme tertiles: 0.11; 95% CI: 0.03, 0.45; P-trend = 0.002) but not after 6- and 9-y of follow-up in multinomial logistic regression models adjusted for baseline frailty status and potential confounders. These results did not differ when analyses were further adjusted for inflammatory markers. Conclusion: Higher habitual dietary resveratrol exposure was associated with lower risk of older community dwellers developing FS during the first 3 y of follow-up but not after longer follow-up periods.

Original languageEnglish
Pages (from-to)1534-1542
Number of pages9
JournalAmerican Journal of Clinical Nutrition
Volume102
Issue number6
DOIs
Publication statusPublished - Dec 1 2015

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resveratrol
Logistic Models
Independent Living
Solid Phase Extraction
Tandem Mass Spectrometry
Liquid Chromatography
Anti-Inflammatory Agents
Eating
Antioxidants
Databases
Food
Population
Surveys and Questionnaires

Keywords

  • Aging
  • Biomarker
  • Diet
  • Epidemiology
  • Frailty
  • InCHIANTI
  • Resveratrol

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Association of habitual dietary resveratrol exposure with the development of frailty in older age : The Invecchiare in Chianti study1,2. / Rabassa, Montserrat; Zamora-Ros, Raul; Urpi-Sarda, Mireia; Bandinelli, Stefania; Ferrucci, Luigi; Andres-Lacueva, Cristina; Cherubini, Antonio.

In: American Journal of Clinical Nutrition, Vol. 102, No. 6, 01.12.2015, p. 1534-1542.

Research output: Contribution to journalArticle

Rabassa, Montserrat ; Zamora-Ros, Raul ; Urpi-Sarda, Mireia ; Bandinelli, Stefania ; Ferrucci, Luigi ; Andres-Lacueva, Cristina ; Cherubini, Antonio. / Association of habitual dietary resveratrol exposure with the development of frailty in older age : The Invecchiare in Chianti study1,2. In: American Journal of Clinical Nutrition. 2015 ; Vol. 102, No. 6. pp. 1534-1542.
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abstract = "Background: Resveratrol may play a protective role against the frailty syndrome (FS) because of its antioxidant and anti-inflammatory properties. Objective: We prospectively evaluated the association between habitual dietary resveratrol exposure and the development of FS after 3-, 6-, and 9-y follow-up periods in a community-dwelling older population. Design: We conducted a longitudinal analysis with the use of data from 769 participants aged $65 y from the Invecchiare in Chianti (Aging in Chianti) study. Total dietary resveratrol (TDR) intake was estimated at baseline with the use of a validated food-frequency questionnaire, which was developed to assess participants' usual food intakes over the previous year, and an ad hoc resveratrol database. Total urinary resveratrol (TUR) was analyzed with the use of liquid chromatography-tandem mass spectrometry with a previous solid-phase extraction at baseline. The combination of both measures [total dietary resveratrol plus total urinary resveratrol (TDR +TUR)] was computed with the use of the Howe's method. FS was assessed at baseline and at 3-, 6-, and 9-y of follow-up and was defined as the presence of $3 of the following 5 criteria: shrinking, exhaustion, sedentariness, slowness, and weakness. Results: TDR+TUR concentrations were inversely associated with FS risk over 3-y of follow-up (OR for comparison of extreme tertiles: 0.11; 95{\%} CI: 0.03, 0.45; P-trend = 0.002) but not after 6- and 9-y of follow-up in multinomial logistic regression models adjusted for baseline frailty status and potential confounders. These results did not differ when analyses were further adjusted for inflammatory markers. Conclusion: Higher habitual dietary resveratrol exposure was associated with lower risk of older community dwellers developing FS during the first 3 y of follow-up but not after longer follow-up periods.",
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AU - Urpi-Sarda, Mireia

AU - Bandinelli, Stefania

AU - Ferrucci, Luigi

AU - Andres-Lacueva, Cristina

AU - Cherubini, Antonio

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N2 - Background: Resveratrol may play a protective role against the frailty syndrome (FS) because of its antioxidant and anti-inflammatory properties. Objective: We prospectively evaluated the association between habitual dietary resveratrol exposure and the development of FS after 3-, 6-, and 9-y follow-up periods in a community-dwelling older population. Design: We conducted a longitudinal analysis with the use of data from 769 participants aged $65 y from the Invecchiare in Chianti (Aging in Chianti) study. Total dietary resveratrol (TDR) intake was estimated at baseline with the use of a validated food-frequency questionnaire, which was developed to assess participants' usual food intakes over the previous year, and an ad hoc resveratrol database. Total urinary resveratrol (TUR) was analyzed with the use of liquid chromatography-tandem mass spectrometry with a previous solid-phase extraction at baseline. The combination of both measures [total dietary resveratrol plus total urinary resveratrol (TDR +TUR)] was computed with the use of the Howe's method. FS was assessed at baseline and at 3-, 6-, and 9-y of follow-up and was defined as the presence of $3 of the following 5 criteria: shrinking, exhaustion, sedentariness, slowness, and weakness. Results: TDR+TUR concentrations were inversely associated with FS risk over 3-y of follow-up (OR for comparison of extreme tertiles: 0.11; 95% CI: 0.03, 0.45; P-trend = 0.002) but not after 6- and 9-y of follow-up in multinomial logistic regression models adjusted for baseline frailty status and potential confounders. These results did not differ when analyses were further adjusted for inflammatory markers. Conclusion: Higher habitual dietary resveratrol exposure was associated with lower risk of older community dwellers developing FS during the first 3 y of follow-up but not after longer follow-up periods.

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