Association of HLA-DRB *0401 allele with chronic pancreatitis

Giulia M. Cavestro, Luca Frulloni, Tauro M. Neri, Pietro Seghini, Antonio Nouvenne, Adele Zanetti, Paolo Bovo, Francesco Di Mario, Lajos Okolicsanyi, Giorgio Cavallini

Research output: Contribution to journalArticle

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Abstract

Introduction: Chronic pancreatitis (CP) is characterized by irreversible morphologic and functional alterations of the pancreas, clinically presenting with upper abdominal pain as well as exocrine and endocrine insufficiencies. According to a more recent hypothesis, the pathogenesis may involve genetic and immunologic factors. Aim: To investigate the major histocompatibility complex (MHC) genes as a genetic background of chronic pancreatitis. Methodology: Allelic polymorphisms were investigated in the genes of the MHC region (HLA B, DRB, DQB) with PCRbased methodologies (PCR-SSP) in 56 patients with CP (44 males and 12 females) and 183 normal controls (78 males and 105 females) of the same ethnic group. All patients and controls gave their informed consent. Results: Among HLA-DRB1 genes, DRB1*04 was significantly higher in CP patients than in controls (26.78% versus 8.1%; pc, <0.003; OR = 4.1; CI = 1.85-9.06). DRB1*04 allele specificities in the DRB1*04-positive patients demonstrated significantly higher frequencies of DRB1*0401 allele (14.3% versus 1.1%; p = 0.00017; OR = 15.08; CI = 3.1-73.36). Neither HLA-B nor HLA-DQB1 associations with the disease were found. Conclusions: This study supports a role of HLA-DRB1*0401 as a susceptibility factor for patients with CP. HLA DRB1*0401 contains the 70QKRAA74 amino acid sequence, which is also expressed by several human pathogens, including Epstein-Barr virus. T cells may be triggered in the pancreatic tissue upon exposure to foreign peptides similar enough to cross-react and to break immunologic tolerance.

Original languageEnglish
Pages (from-to)388-391
Number of pages4
JournalPancreas
Volume26
Issue number4
DOIs
Publication statusPublished - May 2003

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Dichlororibofuranosylbenzimidazole
Chronic Pancreatitis
Alleles
HLA-B Antigens
Major Histocompatibility Complex
Genes
HLA-DRB1 Chains
Immunologic Factors
Informed Consent
Human Herpesvirus 4
Ethnic Groups
Abdominal Pain
Pancreas
Amino Acid Sequence
T-Lymphocytes
Polymerase Chain Reaction
Peptides

Keywords

  • Chronic pancreatitis
  • HLA-DRB1*0401
  • Major histocompatibility complex

ASJC Scopus subject areas

  • Endocrinology
  • Gastroenterology

Cite this

Cavestro, G. M., Frulloni, L., Neri, T. M., Seghini, P., Nouvenne, A., Zanetti, A., ... Cavallini, G. (2003). Association of HLA-DRB *0401 allele with chronic pancreatitis. Pancreas, 26(4), 388-391. https://doi.org/10.1097/00006676-200305000-00013

Association of HLA-DRB *0401 allele with chronic pancreatitis. / Cavestro, Giulia M.; Frulloni, Luca; Neri, Tauro M.; Seghini, Pietro; Nouvenne, Antonio; Zanetti, Adele; Bovo, Paolo; Di Mario, Francesco; Okolicsanyi, Lajos; Cavallini, Giorgio.

In: Pancreas, Vol. 26, No. 4, 05.2003, p. 388-391.

Research output: Contribution to journalArticle

Cavestro, GM, Frulloni, L, Neri, TM, Seghini, P, Nouvenne, A, Zanetti, A, Bovo, P, Di Mario, F, Okolicsanyi, L & Cavallini, G 2003, 'Association of HLA-DRB *0401 allele with chronic pancreatitis', Pancreas, vol. 26, no. 4, pp. 388-391. https://doi.org/10.1097/00006676-200305000-00013
Cavestro GM, Frulloni L, Neri TM, Seghini P, Nouvenne A, Zanetti A et al. Association of HLA-DRB *0401 allele with chronic pancreatitis. Pancreas. 2003 May;26(4):388-391. https://doi.org/10.1097/00006676-200305000-00013
Cavestro, Giulia M. ; Frulloni, Luca ; Neri, Tauro M. ; Seghini, Pietro ; Nouvenne, Antonio ; Zanetti, Adele ; Bovo, Paolo ; Di Mario, Francesco ; Okolicsanyi, Lajos ; Cavallini, Giorgio. / Association of HLA-DRB *0401 allele with chronic pancreatitis. In: Pancreas. 2003 ; Vol. 26, No. 4. pp. 388-391.
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abstract = "Introduction: Chronic pancreatitis (CP) is characterized by irreversible morphologic and functional alterations of the pancreas, clinically presenting with upper abdominal pain as well as exocrine and endocrine insufficiencies. According to a more recent hypothesis, the pathogenesis may involve genetic and immunologic factors. Aim: To investigate the major histocompatibility complex (MHC) genes as a genetic background of chronic pancreatitis. Methodology: Allelic polymorphisms were investigated in the genes of the MHC region (HLA B, DRB, DQB) with PCRbased methodologies (PCR-SSP) in 56 patients with CP (44 males and 12 females) and 183 normal controls (78 males and 105 females) of the same ethnic group. All patients and controls gave their informed consent. Results: Among HLA-DRB1 genes, DRB1*04 was significantly higher in CP patients than in controls (26.78{\%} versus 8.1{\%}; pc, <0.003; OR = 4.1; CI = 1.85-9.06). DRB1*04 allele specificities in the DRB1*04-positive patients demonstrated significantly higher frequencies of DRB1*0401 allele (14.3{\%} versus 1.1{\%}; p = 0.00017; OR = 15.08; CI = 3.1-73.36). Neither HLA-B nor HLA-DQB1 associations with the disease were found. Conclusions: This study supports a role of HLA-DRB1*0401 as a susceptibility factor for patients with CP. HLA DRB1*0401 contains the 70QKRAA74 amino acid sequence, which is also expressed by several human pathogens, including Epstein-Barr virus. T cells may be triggered in the pancreatic tissue upon exposure to foreign peptides similar enough to cross-react and to break immunologic tolerance.",
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T1 - Association of HLA-DRB *0401 allele with chronic pancreatitis

AU - Cavestro, Giulia M.

AU - Frulloni, Luca

AU - Neri, Tauro M.

AU - Seghini, Pietro

AU - Nouvenne, Antonio

AU - Zanetti, Adele

AU - Bovo, Paolo

AU - Di Mario, Francesco

AU - Okolicsanyi, Lajos

AU - Cavallini, Giorgio

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Y1 - 2003/5

N2 - Introduction: Chronic pancreatitis (CP) is characterized by irreversible morphologic and functional alterations of the pancreas, clinically presenting with upper abdominal pain as well as exocrine and endocrine insufficiencies. According to a more recent hypothesis, the pathogenesis may involve genetic and immunologic factors. Aim: To investigate the major histocompatibility complex (MHC) genes as a genetic background of chronic pancreatitis. Methodology: Allelic polymorphisms were investigated in the genes of the MHC region (HLA B, DRB, DQB) with PCRbased methodologies (PCR-SSP) in 56 patients with CP (44 males and 12 females) and 183 normal controls (78 males and 105 females) of the same ethnic group. All patients and controls gave their informed consent. Results: Among HLA-DRB1 genes, DRB1*04 was significantly higher in CP patients than in controls (26.78% versus 8.1%; pc, <0.003; OR = 4.1; CI = 1.85-9.06). DRB1*04 allele specificities in the DRB1*04-positive patients demonstrated significantly higher frequencies of DRB1*0401 allele (14.3% versus 1.1%; p = 0.00017; OR = 15.08; CI = 3.1-73.36). Neither HLA-B nor HLA-DQB1 associations with the disease were found. Conclusions: This study supports a role of HLA-DRB1*0401 as a susceptibility factor for patients with CP. HLA DRB1*0401 contains the 70QKRAA74 amino acid sequence, which is also expressed by several human pathogens, including Epstein-Barr virus. T cells may be triggered in the pancreatic tissue upon exposure to foreign peptides similar enough to cross-react and to break immunologic tolerance.

AB - Introduction: Chronic pancreatitis (CP) is characterized by irreversible morphologic and functional alterations of the pancreas, clinically presenting with upper abdominal pain as well as exocrine and endocrine insufficiencies. According to a more recent hypothesis, the pathogenesis may involve genetic and immunologic factors. Aim: To investigate the major histocompatibility complex (MHC) genes as a genetic background of chronic pancreatitis. Methodology: Allelic polymorphisms were investigated in the genes of the MHC region (HLA B, DRB, DQB) with PCRbased methodologies (PCR-SSP) in 56 patients with CP (44 males and 12 females) and 183 normal controls (78 males and 105 females) of the same ethnic group. All patients and controls gave their informed consent. Results: Among HLA-DRB1 genes, DRB1*04 was significantly higher in CP patients than in controls (26.78% versus 8.1%; pc, <0.003; OR = 4.1; CI = 1.85-9.06). DRB1*04 allele specificities in the DRB1*04-positive patients demonstrated significantly higher frequencies of DRB1*0401 allele (14.3% versus 1.1%; p = 0.00017; OR = 15.08; CI = 3.1-73.36). Neither HLA-B nor HLA-DQB1 associations with the disease were found. Conclusions: This study supports a role of HLA-DRB1*0401 as a susceptibility factor for patients with CP. HLA DRB1*0401 contains the 70QKRAA74 amino acid sequence, which is also expressed by several human pathogens, including Epstein-Barr virus. T cells may be triggered in the pancreatic tissue upon exposure to foreign peptides similar enough to cross-react and to break immunologic tolerance.

KW - Chronic pancreatitis

KW - HLA-DRB10401

KW - Major histocompatibility complex

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