Association of HLA-DRB1 and -DQB1 with classic Kaposi's sarcoma in mainland Italy

Franca Rosa Guerini, Cristina Agliardi, Roberta Mancuso, Lucia Brambilla, Renato Biffi, Silvia Ferrucci, Lorenzo Zanetta, Milena Zanzottera, Marinella Brambati, Vinicio Boneschi, Pasquale Ferrante

Research output: Contribution to journalArticlepeer-review

Abstract

Classic Kaposi's sarcoma (CKS) is a multifocal vascular mesenchymal tumour of unknown origin. Human herpesvirus 8 (HHV8) is now considered to be strongly involved, as a necessary co-factor, though insufficient for development of the disease. Additional identified risk factors include environmental factors, personal habits and genetic susceptibility, with different loci suspected of being risk factors for CKS. Since various human leukocyte antigen (HLA) patterns have been suggested as potential host-related co-factors, the distribution of these alleles was studied in 41 CKS patients, 285 geographically-matched healthy controls (HC) and 17 HHV8-positive controls. Molecular typing of HLA was performed using the polymerase chain reaction sequence-specific primer method (SSP-PCR). Frequency distribution was evaluated by the Chi-squared test with Yates' correction. Odds ratios (OR) and respective 95% confidence limits (CI) were calculated. A significantly higher frequency of HLA-DRB1*13 was observed among the CKS patients (20.7%) compared to the HC (9.8%) (p

Original languageEnglish
Pages (from-to)191-196
Number of pages6
JournalCancer Genomics and Proteomics
Volume3
Issue number3-4
Publication statusPublished - May 2006

Keywords

  • Classic Kaposi's sarcoma
  • Human herpesvirus 8
  • Human leukocyte antigens

ASJC Scopus subject areas

  • Biochemistry
  • Cancer Research
  • Genetics
  • Molecular Biology

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