Association of homocystein (but not MTHFR 677 C>T, MTR 2756 A>G, MTRR 66A>G and TCN2 776 C>G) with ischaemic cerebrovascular disease in Sicily

Paolo Bosco, Rosa Maria Guéant-Rodriguez, Guido Anello, Rosario Spada, Antonino Romano, Adrian Fajardo, Filippo Caraci, Raffaele Ferri, Jean Louis Guéant

Research output: Contribution to journalArticle

Abstract

Association between methylenetetrohydrofolate reductase polymorphism (MTHFR 677 C>T), a determinant of homocysteine plasma level (t-Hcys), with ischaemc cerebrovascular disease (iCVD) seems to be neutral in North Europe and North America. The association of 2756A>G of methionine synthase (MTR), 66 A>G of methionine synthase reductase (MTRR) and 776 C>G of transcobalamin (TCN2) needs to be evaluated further. It was the objective of this study to evaluate the association of these polymorphisms, t-Hcys, vitamin B12 and folate levels with iCVD, in an Italian population from Sicily. We investigated the association of these polymorphisms, t-Hcys, vitamin B12 and folate with iCVD in 252 subjects, including 131 cases and 121 sex- and age-matched healthy controls. t-Hcys was higher in the iCVD group than in controls [15.3 (11.5-17.9) vs. 11.6 (9.4-14.5) μM; P=0.0007] and also in subjects with TCN2 776CG genotype, compared to homozygous genotypes [13.5 (9-9 ± 16.9) vs. 11.7 (9.6 ± 14.4) μM; P=0.0327]. The folate level in cases and controls was consistent with an adequate dietary intake [12.7 (9.0-15.3) vs. 12.5 (9.6-16.9) nM; P=0.7203]. In multivariate analysis, t-Hcys was a significant independent predictor of iCVD with an odds ratio of 1.14 (95 % C.1.: 1.06-1.24; P=0.0006). No association was found between MTHFR, MTR, MTRR and TCN2 polymorphisms and iCVD risk. We have found an influence of t-Hcys and a neutral effect of MTHFR, MTR, MTRR and TCN2 on iCVD risk in Sicily. The neutral influence of these polymorphisms may be explained by adequate status in folate and vitamin B12. Other factors underlying the increased t-Hcys need further investigations.

Original languageEnglish
Pages (from-to)154-159
Number of pages6
JournalThrombosis and Haemostasis
Volume96
Issue number2
DOIs
Publication statusPublished - Aug 2006

Keywords

  • Cerebrovascular disease
  • Folate
  • Homocysteine
  • Methionine synthase reductase
  • Methylenetetrahydrofolate reductase
  • Transcobalamin

ASJC Scopus subject areas

  • Hematology

Fingerprint Dive into the research topics of 'Association of homocystein (but not MTHFR 677 C>T, MTR 2756 A>G, MTRR 66A>G and TCN2 776 C>G) with ischaemic cerebrovascular disease in Sicily'. Together they form a unique fingerprint.

  • Cite this