Association of IL-1 RN*2 allele and methionine synthase 2756 AA genotype with dementia severity of spradic Alzheimer's disease

P. Bosco, R. M. Guéant-Rodríguez, G. Anello, A. Romano, B. Namour, R. S. Spada, F. Caraci, G. Tringali, R. Ferri, J. L. Guéant

Research output: Contribution to journalArticle

Abstract

Background: Genetic polymorphisms of APO-E, homocysteine, and the IL-1 gene cluster (IL-1A, IL-1B, receptor antagonist IL-1RN) are associated with sporadic Alzheimer's disease and may involve interdependent pathways of neuronal toxicity. Objective: To determine whether these polymorphisms and the genetic determinants of homocysteine (methylenetetrahydrofolate reductase, MTHFR; methionine synthase, MTR; transcobalamin, TC) are associated with an increased risk of severe dementia in Alzheimer's disease. Methods: 152 patients with Alzheimer's disease and 136 controls were studied. The association of occurrence and dementia severity (Reisberg score

Original languageEnglish
Pages (from-to)1036-1038
Number of pages3
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume75
Issue number7
DOIs
Publication statusPublished - Jul 2004

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Psychiatry and Mental health

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