Association of immunoglobulin GM allotypes with longevity in long-living individuals from Southern Italy

Annibale A Puca, Anna Ferrario, Anna Maciag, Giulia Accardi, Anna Aiello, Caterina Maria Gambino, Giuseppina Candore, Calogero Caruso, Aryan M Namboodiri, Janardan P Pandey

Research output: Contribution to journalArticle

Abstract

Background: The aim of this study was to analyse the role of GM allotypes, i.e. the hereditary antigenic determinants expressed on immunoglobulin polypeptide chains, in the attainment of longevity. The role played by immunoglobulin allotypes in the control of immune responses is well known as well as the role of an efficient immune response in longevity achievement. So, it is conceivable that particular GM allotypes may contribute to the generation of an efficient immune response that supports successful ageing, hence longevity.

Methods: In order to show if GM allotypes play a role in the achievement of longevity, we typed the DNA of 95 Long-living individuals (LLIs) and 96 young control individuals (YCs) from South Italy for GM3/17 and GM23+/- alleles.

Results: To demonstrate the role of GM allotypes in the attainment of longevity we compared genotype and allele frequencies of GM allotypes between LLIs and YCs. A global chi-square test (3 × 2) shows that the distribution of genotypes at the GM 3/17 locus is highly significantly different in LLIs from that observed in YCs (p < 0.0001). The 2 × 2 chi-square test shows that the carriers of the GM3 allele contribute to this highly significant difference. Accordingly, GM3 allele is significantly overrepresented in LLIs. No significant differences were instead observed regarding GM23 allele.

Conclusion: These preliminary results show that GM3 allotype is significantly overrepresented in LLIs. To best of our knowledge, this is the first study performed to assess the role of GM allotypes in longevity. So, it should be necessary to verify the data in a larger sample of individuals to confirm GM role in the attainment of longevity.

Original languageEnglish
Pages (from-to)26
JournalImmunity and Ageing
Volume15
DOIs
Publication statusPublished - 2018

Fingerprint

Immunoglobulin Allotypes
Italy
Alleles
Chi-Square Distribution
Immunoglobulin Subunits
Genotype
Gene Frequency
Epitopes
DNA

Cite this

Association of immunoglobulin GM allotypes with longevity in long-living individuals from Southern Italy. / Puca, Annibale A; Ferrario, Anna; Maciag, Anna; Accardi, Giulia; Aiello, Anna; Gambino, Caterina Maria; Candore, Giuseppina; Caruso, Calogero; Namboodiri, Aryan M; Pandey, Janardan P.

In: Immunity and Ageing, Vol. 15, 2018, p. 26.

Research output: Contribution to journalArticle

Puca, Annibale A ; Ferrario, Anna ; Maciag, Anna ; Accardi, Giulia ; Aiello, Anna ; Gambino, Caterina Maria ; Candore, Giuseppina ; Caruso, Calogero ; Namboodiri, Aryan M ; Pandey, Janardan P. / Association of immunoglobulin GM allotypes with longevity in long-living individuals from Southern Italy. In: Immunity and Ageing. 2018 ; Vol. 15. pp. 26.
@article{ff75870bd09d40b5847efe6600e2f833,
title = "Association of immunoglobulin GM allotypes with longevity in long-living individuals from Southern Italy",
abstract = "Background: The aim of this study was to analyse the role of GM allotypes, i.e. the hereditary antigenic determinants expressed on immunoglobulin polypeptide chains, in the attainment of longevity. The role played by immunoglobulin allotypes in the control of immune responses is well known as well as the role of an efficient immune response in longevity achievement. So, it is conceivable that particular GM allotypes may contribute to the generation of an efficient immune response that supports successful ageing, hence longevity.Methods: In order to show if GM allotypes play a role in the achievement of longevity, we typed the DNA of 95 Long-living individuals (LLIs) and 96 young control individuals (YCs) from South Italy for GM3/17 and GM23+/- alleles.Results: To demonstrate the role of GM allotypes in the attainment of longevity we compared genotype and allele frequencies of GM allotypes between LLIs and YCs. A global chi-square test (3 × 2) shows that the distribution of genotypes at the GM 3/17 locus is highly significantly different in LLIs from that observed in YCs (p < 0.0001). The 2 × 2 chi-square test shows that the carriers of the GM3 allele contribute to this highly significant difference. Accordingly, GM3 allele is significantly overrepresented in LLIs. No significant differences were instead observed regarding GM23 allele.Conclusion: These preliminary results show that GM3 allotype is significantly overrepresented in LLIs. To best of our knowledge, this is the first study performed to assess the role of GM allotypes in longevity. So, it should be necessary to verify the data in a larger sample of individuals to confirm GM role in the attainment of longevity.",
author = "Puca, {Annibale A} and Anna Ferrario and Anna Maciag and Giulia Accardi and Anna Aiello and Gambino, {Caterina Maria} and Giuseppina Candore and Calogero Caruso and Namboodiri, {Aryan M} and Pandey, {Janardan P}",
year = "2018",
doi = "10.1186/s12979-018-0134-7",
language = "English",
volume = "15",
pages = "26",
journal = "Immunity and Ageing",
issn = "1742-4933",
publisher = "BioMed Central",

}

TY - JOUR

T1 - Association of immunoglobulin GM allotypes with longevity in long-living individuals from Southern Italy

AU - Puca, Annibale A

AU - Ferrario, Anna

AU - Maciag, Anna

AU - Accardi, Giulia

AU - Aiello, Anna

AU - Gambino, Caterina Maria

AU - Candore, Giuseppina

AU - Caruso, Calogero

AU - Namboodiri, Aryan M

AU - Pandey, Janardan P

PY - 2018

Y1 - 2018

N2 - Background: The aim of this study was to analyse the role of GM allotypes, i.e. the hereditary antigenic determinants expressed on immunoglobulin polypeptide chains, in the attainment of longevity. The role played by immunoglobulin allotypes in the control of immune responses is well known as well as the role of an efficient immune response in longevity achievement. So, it is conceivable that particular GM allotypes may contribute to the generation of an efficient immune response that supports successful ageing, hence longevity.Methods: In order to show if GM allotypes play a role in the achievement of longevity, we typed the DNA of 95 Long-living individuals (LLIs) and 96 young control individuals (YCs) from South Italy for GM3/17 and GM23+/- alleles.Results: To demonstrate the role of GM allotypes in the attainment of longevity we compared genotype and allele frequencies of GM allotypes between LLIs and YCs. A global chi-square test (3 × 2) shows that the distribution of genotypes at the GM 3/17 locus is highly significantly different in LLIs from that observed in YCs (p < 0.0001). The 2 × 2 chi-square test shows that the carriers of the GM3 allele contribute to this highly significant difference. Accordingly, GM3 allele is significantly overrepresented in LLIs. No significant differences were instead observed regarding GM23 allele.Conclusion: These preliminary results show that GM3 allotype is significantly overrepresented in LLIs. To best of our knowledge, this is the first study performed to assess the role of GM allotypes in longevity. So, it should be necessary to verify the data in a larger sample of individuals to confirm GM role in the attainment of longevity.

AB - Background: The aim of this study was to analyse the role of GM allotypes, i.e. the hereditary antigenic determinants expressed on immunoglobulin polypeptide chains, in the attainment of longevity. The role played by immunoglobulin allotypes in the control of immune responses is well known as well as the role of an efficient immune response in longevity achievement. So, it is conceivable that particular GM allotypes may contribute to the generation of an efficient immune response that supports successful ageing, hence longevity.Methods: In order to show if GM allotypes play a role in the achievement of longevity, we typed the DNA of 95 Long-living individuals (LLIs) and 96 young control individuals (YCs) from South Italy for GM3/17 and GM23+/- alleles.Results: To demonstrate the role of GM allotypes in the attainment of longevity we compared genotype and allele frequencies of GM allotypes between LLIs and YCs. A global chi-square test (3 × 2) shows that the distribution of genotypes at the GM 3/17 locus is highly significantly different in LLIs from that observed in YCs (p < 0.0001). The 2 × 2 chi-square test shows that the carriers of the GM3 allele contribute to this highly significant difference. Accordingly, GM3 allele is significantly overrepresented in LLIs. No significant differences were instead observed regarding GM23 allele.Conclusion: These preliminary results show that GM3 allotype is significantly overrepresented in LLIs. To best of our knowledge, this is the first study performed to assess the role of GM allotypes in longevity. So, it should be necessary to verify the data in a larger sample of individuals to confirm GM role in the attainment of longevity.

U2 - 10.1186/s12979-018-0134-7

DO - 10.1186/s12979-018-0134-7

M3 - Article

C2 - 30450119

VL - 15

SP - 26

JO - Immunity and Ageing

JF - Immunity and Ageing

SN - 1742-4933

ER -