Abstract
Patients with peripheral arterial disease have a high risk of death from cardiovascular events. As defective fibrinolysis associated with leg atherosclerosis has been suggested as a predisposing factor, we sought a relation among decreased fibrinolysis, the presence of leg atherosclerosis and the incidence of thrombotic events in a case-control study nested in the PLAT. Fifty-eight patients with coronary and/or cerebral atherothrombotic disease, free of leg atherosclerosis at Doppler examination, were compared with 50 atherosclerotic patients with leg involvement. High D-dimer (153.0 vs 81.3 ng/ml, p <0.001) and tPA antigen before venous stasis (14.4 vs 11.8 ng/ml, p <0.03), and low tPA antigen (6.7 vs 15.6 ng/ml, p <0.01) and fibrinolytic activity released after venous stasis (fibrinolytic capacity: 113.2 vs 281.4 mm2, p <0.001) were found in patients with leg atherosclerosis. D-dimer and fibrinolytic capacity, in addition to age, were selected by stepwise discriminant analysis as characterizing patients with leg atherosclerosis. Moreover, higher D-dimer and tPA inhibitor characterized patients with leg atherosclerosis who subsequently experienced thrombotic events. These findings constitute evidence of high fibrin turnover and impaired fibrinolytic potential in patients with leg atherosclerosis. Thus impaired fibrinolysis may contribute to the prothrombotic state in these patients.
| Original language | English |
|---|---|
| Pages (from-to) | 292-296 |
| Number of pages | 5 |
| Journal | Thrombosis and Haemostasis |
| Volume | 72 |
| Issue number | 2 |
| Publication status | Published - 1994 |
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ASJC Scopus subject areas
- Hematology
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Association of increased fibrin turnover and defective fibrinolytic capacity with leg atherosclerosis. / Cortellaro, M.; Cofrancesco, E.; Boschetti, C.; Mussoni, L.; Donati, M. B.; Catalano, M.; Gabrielli, L.; Lombardi, B.; Specchia, G.; Tavazzi, L.; Tremoli, E.; Turri, M.; Rainisio, M.; Gentile, G.; Moreo, G.; Cardillo, M.; Bianchi, O.; Leonardi, P.; Columbi, M.
In: Thrombosis and Haemostasis, Vol. 72, No. 2, 1994, p. 292-296.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association of increased fibrin turnover and defective fibrinolytic capacity with leg atherosclerosis
AU - Cortellaro, M.
AU - Cofrancesco, E.
AU - Boschetti, C.
AU - Mussoni, L.
AU - Donati, M. B.
AU - Catalano, M.
AU - Gabrielli, L.
AU - Lombardi, B.
AU - Specchia, G.
AU - Tavazzi, L.
AU - Tremoli, E.
AU - Turri, M.
AU - Rainisio, M.
AU - Gentile, G.
AU - Moreo, G.
AU - Cardillo, M.
AU - Bianchi, O.
AU - Leonardi, P.
AU - Columbi, M.
PY - 1994
Y1 - 1994
N2 - Patients with peripheral arterial disease have a high risk of death from cardiovascular events. As defective fibrinolysis associated with leg atherosclerosis has been suggested as a predisposing factor, we sought a relation among decreased fibrinolysis, the presence of leg atherosclerosis and the incidence of thrombotic events in a case-control study nested in the PLAT. Fifty-eight patients with coronary and/or cerebral atherothrombotic disease, free of leg atherosclerosis at Doppler examination, were compared with 50 atherosclerotic patients with leg involvement. High D-dimer (153.0 vs 81.3 ng/ml, p <0.001) and tPA antigen before venous stasis (14.4 vs 11.8 ng/ml, p <0.03), and low tPA antigen (6.7 vs 15.6 ng/ml, p <0.01) and fibrinolytic activity released after venous stasis (fibrinolytic capacity: 113.2 vs 281.4 mm2, p <0.001) were found in patients with leg atherosclerosis. D-dimer and fibrinolytic capacity, in addition to age, were selected by stepwise discriminant analysis as characterizing patients with leg atherosclerosis. Moreover, higher D-dimer and tPA inhibitor characterized patients with leg atherosclerosis who subsequently experienced thrombotic events. These findings constitute evidence of high fibrin turnover and impaired fibrinolytic potential in patients with leg atherosclerosis. Thus impaired fibrinolysis may contribute to the prothrombotic state in these patients.
AB - Patients with peripheral arterial disease have a high risk of death from cardiovascular events. As defective fibrinolysis associated with leg atherosclerosis has been suggested as a predisposing factor, we sought a relation among decreased fibrinolysis, the presence of leg atherosclerosis and the incidence of thrombotic events in a case-control study nested in the PLAT. Fifty-eight patients with coronary and/or cerebral atherothrombotic disease, free of leg atherosclerosis at Doppler examination, were compared with 50 atherosclerotic patients with leg involvement. High D-dimer (153.0 vs 81.3 ng/ml, p <0.001) and tPA antigen before venous stasis (14.4 vs 11.8 ng/ml, p <0.03), and low tPA antigen (6.7 vs 15.6 ng/ml, p <0.01) and fibrinolytic activity released after venous stasis (fibrinolytic capacity: 113.2 vs 281.4 mm2, p <0.001) were found in patients with leg atherosclerosis. D-dimer and fibrinolytic capacity, in addition to age, were selected by stepwise discriminant analysis as characterizing patients with leg atherosclerosis. Moreover, higher D-dimer and tPA inhibitor characterized patients with leg atherosclerosis who subsequently experienced thrombotic events. These findings constitute evidence of high fibrin turnover and impaired fibrinolytic potential in patients with leg atherosclerosis. Thus impaired fibrinolysis may contribute to the prothrombotic state in these patients.
UR - http://www.scopus.com/inward/record.url?scp=0027978514&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027978514&partnerID=8YFLogxK
M3 - Article
C2 - 7831667
AN - SCOPUS:0027978514
VL - 72
SP - 292
EP - 296
JO - Thrombosis and Haemostasis
JF - Thrombosis and Haemostasis
SN - 0340-6245
IS - 2
ER -