Association of interferon-γ +874A polymorphism with reduced long-term inflammatory response in haemodialysis patients

Gianni Biolo, Antonio Amoroso, Silvana Savoldi, Alessandra Bosutti, Massimiliano Martone, Doroti Pirulli, Francesco Bianco, Sheila Ulivi, Sara Bertok, Mary Artero, Rocco Barazzoni, Michela Zanetti, Gabriele Grassi, Gianfranco Guarnieri, Giovanni Panzetta

Research output: Contribution to journalArticlepeer-review

Abstract

Background. We have studied the effects of interferon (IFN)-γ allelic variations on expression levels of pro- and anti-inflammatory cytokines and on long-term inflammatory status in haemodialysis patients. Methods. Genotyping was performed in 123 patients for single nucleotide polymorphisms in the first intron of the IFN-γ gene (+874 T/A). They were prospectively followed for 2 years. Cytokine mRNA levels in whole blood cells (detected by real time (RT)-PCR technique) and serum C-reactive protein (CRP) concentrations were compared in patient groups with different IFN-γ genotypes. Serum CRP was evaluated every month and inflammatory state was defined as percent of abnormal values (above 5 mg/l) over total determinations. Of the total, 102 patients survived and completed 24±1 monthly CRP determinations. The IFN-γ ±874 A/A, 'low-producer' genotype was associated with decreased (P

Original languageEnglish
Pages (from-to)1317-1322
Number of pages6
JournalNephrology Dialysis Transplantation
Volume21
Issue number5
DOIs
Publication statusPublished - May 2006

Keywords

  • C-reactive protein
  • Chronic renal failure
  • Haemodialysis
  • Inflammation
  • Interferon-gamma
  • Polymorphisms

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

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