Abstract
Background. We have studied the effects of interferon (IFN)-γ allelic variations on expression levels of pro- and anti-inflammatory cytokines and on long-term inflammatory status in haemodialysis patients. Methods. Genotyping was performed in 123 patients for single nucleotide polymorphisms in the first intron of the IFN-γ gene (+874 T/A). They were prospectively followed for 2 years. Cytokine mRNA levels in whole blood cells (detected by real time (RT)-PCR technique) and serum C-reactive protein (CRP) concentrations were compared in patient groups with different IFN-γ genotypes. Serum CRP was evaluated every month and inflammatory state was defined as percent of abnormal values (above 5 mg/l) over total determinations. Of the total, 102 patients survived and completed 24±1 monthly CRP determinations. The IFN-γ ±874 A/A, 'low-producer' genotype was associated with decreased (P
Original language | English |
---|---|
Pages (from-to) | 1317-1322 |
Number of pages | 6 |
Journal | Nephrology Dialysis Transplantation |
Volume | 21 |
Issue number | 5 |
DOIs | |
Publication status | Published - May 2006 |
Keywords
- C-reactive protein
- Chronic renal failure
- Haemodialysis
- Inflammation
- Interferon-gamma
- Polymorphisms
ASJC Scopus subject areas
- Nephrology
- Transplantation