Association of interferon-γ +874A polymorphism with reduced long-term inflammatory response in haemodialysis patients

Gianni Biolo; Antonio Amoroso; Silvana Savoldi; Alessandra Bosutti; Massimiliano Martone; Doroti Pirulli; Francesco Bianco; Sheila Ulivi; Sara Bertok; Mary Artero; Rocco Barazzoni; Michela Zanetti; Gabriele Grassi; Gianfranco Guarnieri; Giovanni Panzetta

doi:10.1093/ndt/gfk033

Association of interferon-γ +874A polymorphism with reduced long-term inflammatory response in haemodialysis patients

Gianni Biolo, Antonio Amoroso, Silvana Savoldi, Alessandra Bosutti, Massimiliano Martone, Doroti Pirulli, Francesco Bianco, Sheila Ulivi, Sara Bertok, Mary Artero, Rocco Barazzoni, Michela Zanetti, Gabriele Grassi, Gianfranco Guarnieri, Giovanni Panzetta

IRCCS pediatrico Burlo Garofolo

Research output: Contribution to journal › Article › peer-review

Abstract

Background. We have studied the effects of interferon (IFN)-γ allelic variations on expression levels of pro- and anti-inflammatory cytokines and on long-term inflammatory status in haemodialysis patients. Methods. Genotyping was performed in 123 patients for single nucleotide polymorphisms in the first intron of the IFN-γ gene (+874 T/A). They were prospectively followed for 2 years. Cytokine mRNA levels in whole blood cells (detected by real time (RT)-PCR technique) and serum C-reactive protein (CRP) concentrations were compared in patient groups with different IFN-γ genotypes. Serum CRP was evaluated every month and inflammatory state was defined as percent of abnormal values (above 5 mg/l) over total determinations. Of the total, 102 patients survived and completed 24±1 monthly CRP determinations. The IFN-γ ±874 A/A, 'low-producer' genotype was associated with decreased (P

Original language	English
Pages (from-to)	1317-1322
Number of pages	6
Journal	Nephrology Dialysis Transplantation
Volume	21
Issue number	5
DOIs	https://doi.org/10.1093/ndt/gfk033
Publication status	Published - May 2006

Keywords

C-reactive protein
Chronic renal failure
Haemodialysis
Inflammation
Interferon-gamma
Polymorphisms

ASJC Scopus subject areas

Nephrology
Transplantation

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10.1093/ndt/gfk033

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Biolo, G., Amoroso, A., Savoldi, S., Bosutti, A., Martone, M., Pirulli, D., Bianco, F., Ulivi, S., Bertok, S., Artero, M., Barazzoni, R., Zanetti, M., Grassi, G., Guarnieri, G., & Panzetta, G. (2006). Association of interferon-γ +874A polymorphism with reduced long-term inflammatory response in haemodialysis patients. Nephrology Dialysis Transplantation, 21(5), 1317-1322. https://doi.org/10.1093/ndt/gfk033

Biolo, G, Amoroso, A, Savoldi, S, Bosutti, A, Martone, M, Pirulli, D, Bianco, F, Ulivi, S, Bertok, S, Artero, M, Barazzoni, R, Zanetti, M, Grassi, G, Guarnieri, G & Panzetta, G 2006, 'Association of interferon-γ +874A polymorphism with reduced long-term inflammatory response in haemodialysis patients', Nephrology Dialysis Transplantation, vol. 21, no. 5, pp. 1317-1322. https://doi.org/10.1093/ndt/gfk033

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abstract = "Background. We have studied the effects of interferon (IFN)-γ allelic variations on expression levels of pro- and anti-inflammatory cytokines and on long-term inflammatory status in haemodialysis patients. Methods. Genotyping was performed in 123 patients for single nucleotide polymorphisms in the first intron of the IFN-γ gene (+874 T/A). They were prospectively followed for 2 years. Cytokine mRNA levels in whole blood cells (detected by real time (RT)-PCR technique) and serum C-reactive protein (CRP) concentrations were compared in patient groups with different IFN-γ genotypes. Serum CRP was evaluated every month and inflammatory state was defined as percent of abnormal values (above 5 mg/l) over total determinations. Of the total, 102 patients survived and completed 24±1 monthly CRP determinations. The IFN-γ ±874 A/A, 'low-producer' genotype was associated with decreased (P ",

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author = "Gianni Biolo and Antonio Amoroso and Silvana Savoldi and Alessandra Bosutti and Massimiliano Martone and Doroti Pirulli and Francesco Bianco and Sheila Ulivi and Sara Bertok and Mary Artero and Rocco Barazzoni and Michela Zanetti and Gabriele Grassi and Gianfranco Guarnieri and Giovanni Panzetta",

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doi = "10.1093/ndt/gfk033",

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AU - Biolo, Gianni

AU - Amoroso, Antonio

AU - Savoldi, Silvana

AU - Bosutti, Alessandra

AU - Martone, Massimiliano

AU - Pirulli, Doroti

AU - Bianco, Francesco

AU - Ulivi, Sheila

AU - Bertok, Sara

AU - Artero, Mary

AU - Barazzoni, Rocco

AU - Zanetti, Michela

AU - Grassi, Gabriele

AU - Guarnieri, Gianfranco

AU - Panzetta, Giovanni

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N2 - Background. We have studied the effects of interferon (IFN)-γ allelic variations on expression levels of pro- and anti-inflammatory cytokines and on long-term inflammatory status in haemodialysis patients. Methods. Genotyping was performed in 123 patients for single nucleotide polymorphisms in the first intron of the IFN-γ gene (+874 T/A). They were prospectively followed for 2 years. Cytokine mRNA levels in whole blood cells (detected by real time (RT)-PCR technique) and serum C-reactive protein (CRP) concentrations were compared in patient groups with different IFN-γ genotypes. Serum CRP was evaluated every month and inflammatory state was defined as percent of abnormal values (above 5 mg/l) over total determinations. Of the total, 102 patients survived and completed 24±1 monthly CRP determinations. The IFN-γ ±874 A/A, 'low-producer' genotype was associated with decreased (P

AB - Background. We have studied the effects of interferon (IFN)-γ allelic variations on expression levels of pro- and anti-inflammatory cytokines and on long-term inflammatory status in haemodialysis patients. Methods. Genotyping was performed in 123 patients for single nucleotide polymorphisms in the first intron of the IFN-γ gene (+874 T/A). They were prospectively followed for 2 years. Cytokine mRNA levels in whole blood cells (detected by real time (RT)-PCR technique) and serum C-reactive protein (CRP) concentrations were compared in patient groups with different IFN-γ genotypes. Serum CRP was evaluated every month and inflammatory state was defined as percent of abnormal values (above 5 mg/l) over total determinations. Of the total, 102 patients survived and completed 24±1 monthly CRP determinations. The IFN-γ ±874 A/A, 'low-producer' genotype was associated with decreased (P

KW - C-reactive protein

KW - Chronic renal failure

KW - Haemodialysis

KW - Inflammation

KW - Interferon-gamma

KW - Polymorphisms

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Association of interferon-γ +874A polymorphism with reduced long-term inflammatory response in haemodialysis patients

Abstract

Keywords

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