Association of interferon-induced helicase C domain (IFIH1) gene polymorphisms with systemic lupus erythematosus and a relevant updated meta-analysis

J. De Azevedo Silva, S. C. Lima, C. Addobbati, R. Moura, L. A. Cavalcanti Brandão, J. A. Trés Pancoto, E. A. Donadi, S. Crovella, P. Sandrin-Garcia

Research output: Contribution to journalArticle

Abstract

Systemic lupus erythematosus (SLE) is a complex autoimmune disorder presenting heterogeneous clinical manifestations. A number of genes involved in SLE susceptibility are related to the type I interferon (IFN) pathway. IFN mediates innate immune responses and its increased levels contribute to the breakdown of peripheral tolerance. Interferon-induced helicase C domain 1 (IFIH1) activates and modulates IFN responses through its caspase recruitment domain. In this study, we analyzed four IFIH1 single nucleotide polymorphisms (SNPs): rs6432714, rs10930046, rs1990760, and rs3747517, in 337 patients with SLE and 373 healthy individuals from southeast and northeast Brazil. Our results did not find an association between IFIH1 SNPs and SLE (P value >0.025 after Bonferroni’s adjustment). However, meta-analysis of peer-reviewed articles from 2008 to 2015 and data from this study indicated an association between rs1990760 and SLE onset (P < 0.05). This is the first association analysis on IFIH1 polymorphisms and SLE susceptibility in Brazilian populations.

Original languageEnglish
Article numbergmr15048008
JournalGenetics and Molecular Research
Volume15
Issue number4
DOIs
Publication statusPublished - Oct 24 2016

Keywords

  • IFIH1
  • Meta-analysis
  • SLE
  • SLE clinical manifestations
  • SNPs

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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    De Azevedo Silva, J., Lima, S. C., Addobbati, C., Moura, R., Cavalcanti Brandão, L. A., Trés Pancoto, J. A., Donadi, E. A., Crovella, S., & Sandrin-Garcia, P. (2016). Association of interferon-induced helicase C domain (IFIH1) gene polymorphisms with systemic lupus erythematosus and a relevant updated meta-analysis. Genetics and Molecular Research, 15(4), [gmr15048008]. https://doi.org/10.4238/gmr15048008