Abstract
Background. Keratin 8 (K8) and 18 (K18) are the major components of the intermediate filament cytoskeleton of pancreatic acinar cells and play a relevant role in pancreatic exocrine homeostasis. Transgenic mice for K8 have shown to display progressive exocrine pancreas alterations, including dysplasia, loss of acinar architecture, redifferentiation of acinar to ductal cells, inflammation, fibrosis, and substitution of exocrine tissue by adipose tissue. Aim. To investigate whether mutations in the keratin 8 gene are associated with chronic pancreatitis. Methods. Mutations in the keratin 8 gene were determined by polymerase chain reaction/restriction fragment length polymorphism in 67 chronic pancreatitis patients and 100 normal controls. Sequence analysis was performed when necessary. Results. Glycine-to-cysteine mutations at position 61 (G61C) of the keratin 8 gene were found in six patients (8.9 vs. 0%, pc
| Original language | English |
|---|---|
| Pages (from-to) | 416-420 |
| Number of pages | 5 |
| Journal | Digestive and Liver Disease |
| Volume | 35 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun 2003 |
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Keywords
- Chronic pancreatitis
- Genetics
- Keratin 8 mutations
ASJC Scopus subject areas
- Gastroenterology
Cite this
Association of keratin 8 gene mutation with chronic pancreatitis. / Cavestro, Giulia Martina; Frulloni, L.; Nouvenne, A.; Neri, T. M.; Calore, B.; Ferri, B.; Bovo, P.; Okolicsanyi, L.; Di Mario, F.; Cavallini, G.
In: Digestive and Liver Disease, Vol. 35, No. 6, 06.2003, p. 416-420.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association of keratin 8 gene mutation with chronic pancreatitis
AU - Cavestro, Giulia Martina
AU - Frulloni, L.
AU - Nouvenne, A.
AU - Neri, T. M.
AU - Calore, B.
AU - Ferri, B.
AU - Bovo, P.
AU - Okolicsanyi, L.
AU - Di Mario, F.
AU - Cavallini, G.
PY - 2003/6
Y1 - 2003/6
N2 - Background. Keratin 8 (K8) and 18 (K18) are the major components of the intermediate filament cytoskeleton of pancreatic acinar cells and play a relevant role in pancreatic exocrine homeostasis. Transgenic mice for K8 have shown to display progressive exocrine pancreas alterations, including dysplasia, loss of acinar architecture, redifferentiation of acinar to ductal cells, inflammation, fibrosis, and substitution of exocrine tissue by adipose tissue. Aim. To investigate whether mutations in the keratin 8 gene are associated with chronic pancreatitis. Methods. Mutations in the keratin 8 gene were determined by polymerase chain reaction/restriction fragment length polymorphism in 67 chronic pancreatitis patients and 100 normal controls. Sequence analysis was performed when necessary. Results. Glycine-to-cysteine mutations at position 61 (G61C) of the keratin 8 gene were found in six patients (8.9 vs. 0%, pc
AB - Background. Keratin 8 (K8) and 18 (K18) are the major components of the intermediate filament cytoskeleton of pancreatic acinar cells and play a relevant role in pancreatic exocrine homeostasis. Transgenic mice for K8 have shown to display progressive exocrine pancreas alterations, including dysplasia, loss of acinar architecture, redifferentiation of acinar to ductal cells, inflammation, fibrosis, and substitution of exocrine tissue by adipose tissue. Aim. To investigate whether mutations in the keratin 8 gene are associated with chronic pancreatitis. Methods. Mutations in the keratin 8 gene were determined by polymerase chain reaction/restriction fragment length polymorphism in 67 chronic pancreatitis patients and 100 normal controls. Sequence analysis was performed when necessary. Results. Glycine-to-cysteine mutations at position 61 (G61C) of the keratin 8 gene were found in six patients (8.9 vs. 0%, pc
KW - Chronic pancreatitis
KW - Genetics
KW - Keratin 8 mutations
UR - http://www.scopus.com/inward/record.url?scp=0142093584&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0142093584&partnerID=8YFLogxK
U2 - 10.1016/S1590-8658(03)00159-2
DO - 10.1016/S1590-8658(03)00159-2
M3 - Article
VL - 35
SP - 416
EP - 420
JO - Digestive and Liver Disease
JF - Digestive and Liver Disease
SN - 1590-8658
IS - 6
ER -