Association of keratin 8 gene mutation with chronic pancreatitis

Giulia Martina Cavestro, L. Frulloni, A. Nouvenne, T. M. Neri, B. Calore, B. Ferri, P. Bovo, L. Okolicsanyi, F. Di Mario, G. Cavallini

Research output: Contribution to journalArticle

Abstract

Background. Keratin 8 (K8) and 18 (K18) are the major components of the intermediate filament cytoskeleton of pancreatic acinar cells and play a relevant role in pancreatic exocrine homeostasis. Transgenic mice for K8 have shown to display progressive exocrine pancreas alterations, including dysplasia, loss of acinar architecture, redifferentiation of acinar to ductal cells, inflammation, fibrosis, and substitution of exocrine tissue by adipose tissue. Aim. To investigate whether mutations in the keratin 8 gene are associated with chronic pancreatitis. Methods. Mutations in the keratin 8 gene were determined by polymerase chain reaction/restriction fragment length polymorphism in 67 chronic pancreatitis patients and 100 normal controls. Sequence analysis was performed when necessary. Results. Glycine-to-cysteine mutations at position 61 (G61C) of the keratin 8 gene were found in six patients (8.9 vs. 0%, pc

Original languageEnglish
Pages (from-to)416-420
Number of pages5
JournalDigestive and Liver Disease
Volume35
Issue number6
DOIs
Publication statusPublished - Jun 2003

Keywords

  • Chronic pancreatitis
  • Genetics
  • Keratin 8 mutations

ASJC Scopus subject areas

  • Gastroenterology

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    Cavestro, G. M., Frulloni, L., Nouvenne, A., Neri, T. M., Calore, B., Ferri, B., Bovo, P., Okolicsanyi, L., Di Mario, F., & Cavallini, G. (2003). Association of keratin 8 gene mutation with chronic pancreatitis. Digestive and Liver Disease, 35(6), 416-420. https://doi.org/10.1016/S1590-8658(03)00159-2