Abstract
AIMS: To assess the role of kidney disease measures on the development of chronic kidney disease (CKD) in patients with type 2 diabetes (T2D) and hypertension (HT).
METHODS: Clinical records from a total of 17,160 patients with T2D and HT, a baseline estimated glomerular filtration rate (eGFR) values ≥60mL/min/1.73m(2), evaluation for albuminuria and regular visits during a four-year follow-up were retrieved and analyzed. The incidence of eGFR <60mL/min/1.73m(2) and/or a reduction >30% from baseline was evaluated.
RESULTS: At baseline 23% of patients (n=3873) had albuminuria. Over the 4-year follow-up 20% (n=3480) developed a renal endpoint 28% (n=1074) of those with albuminuria and 17% (n=2406) of those without albuminuria. The presence of baseline albuminuria entailed a 1.8 independent, greater risk of reaching stage 3 CKD. Patients with normal albuminuria showed a 1.54 (p<0.001) greater risk for each 5mL reduction (below 90mL/min) in baseline GFR.
CONCLUSIONS: In T2D patients with HT, eGFR reduction and albuminuria are independently associated with a greater risk of developing stage 3 CKD. While baseline albuminuria entails a greater renal risk, due to a larger occurrence of the non-albuminuric phenotype, renal function worsening is more likely to be observed in patients without albuminuria.
| Original language | English |
|---|---|
| Pages (from-to) | 419-426 |
| Number of pages | 8 |
| Journal | Journal of Diabetes and its Complications |
| Volume | 31 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2017 |
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- Journal Article
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Association of kidney disease measures with risk of renal function worsening in patients with hypertension and type 2 diabetes. / Viazzi, Francesca; Piscitelli, Angela Pamela; Giorda, Carlo; Ceriello, Antonio; Genovese, Stefano; Russo, Giuseppina T; Fioretto, Paola; Guida, Pietro; De Cosmo, Salvatore; Pontremoli, Roberto; AMD-Annals Study Group.
In: Journal of Diabetes and its Complications, Vol. 31, No. 2, 02.2017, p. 419-426.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association of kidney disease measures with risk of renal function worsening in patients with hypertension and type 2 diabetes
AU - Viazzi, Francesca
AU - Piscitelli, Angela Pamela
AU - Giorda, Carlo
AU - Ceriello, Antonio
AU - Genovese, Stefano
AU - Russo, Giuseppina T
AU - Fioretto, Paola
AU - Guida, Pietro
AU - De Cosmo, Salvatore
AU - Pontremoli, Roberto
AU - AMD-Annals Study Group
N1 - Copyright © 2016 Elsevier Inc. All rights reserved.
PY - 2017/2
Y1 - 2017/2
N2 - AIMS: To assess the role of kidney disease measures on the development of chronic kidney disease (CKD) in patients with type 2 diabetes (T2D) and hypertension (HT).METHODS: Clinical records from a total of 17,160 patients with T2D and HT, a baseline estimated glomerular filtration rate (eGFR) values ≥60mL/min/1.73m(2), evaluation for albuminuria and regular visits during a four-year follow-up were retrieved and analyzed. The incidence of eGFR <60mL/min/1.73m(2) and/or a reduction >30% from baseline was evaluated.RESULTS: At baseline 23% of patients (n=3873) had albuminuria. Over the 4-year follow-up 20% (n=3480) developed a renal endpoint 28% (n=1074) of those with albuminuria and 17% (n=2406) of those without albuminuria. The presence of baseline albuminuria entailed a 1.8 independent, greater risk of reaching stage 3 CKD. Patients with normal albuminuria showed a 1.54 (p<0.001) greater risk for each 5mL reduction (below 90mL/min) in baseline GFR.CONCLUSIONS: In T2D patients with HT, eGFR reduction and albuminuria are independently associated with a greater risk of developing stage 3 CKD. While baseline albuminuria entails a greater renal risk, due to a larger occurrence of the non-albuminuric phenotype, renal function worsening is more likely to be observed in patients without albuminuria.
AB - AIMS: To assess the role of kidney disease measures on the development of chronic kidney disease (CKD) in patients with type 2 diabetes (T2D) and hypertension (HT).METHODS: Clinical records from a total of 17,160 patients with T2D and HT, a baseline estimated glomerular filtration rate (eGFR) values ≥60mL/min/1.73m(2), evaluation for albuminuria and regular visits during a four-year follow-up were retrieved and analyzed. The incidence of eGFR <60mL/min/1.73m(2) and/or a reduction >30% from baseline was evaluated.RESULTS: At baseline 23% of patients (n=3873) had albuminuria. Over the 4-year follow-up 20% (n=3480) developed a renal endpoint 28% (n=1074) of those with albuminuria and 17% (n=2406) of those without albuminuria. The presence of baseline albuminuria entailed a 1.8 independent, greater risk of reaching stage 3 CKD. Patients with normal albuminuria showed a 1.54 (p<0.001) greater risk for each 5mL reduction (below 90mL/min) in baseline GFR.CONCLUSIONS: In T2D patients with HT, eGFR reduction and albuminuria are independently associated with a greater risk of developing stage 3 CKD. While baseline albuminuria entails a greater renal risk, due to a larger occurrence of the non-albuminuric phenotype, renal function worsening is more likely to be observed in patients without albuminuria.
KW - Journal Article
U2 - 10.1016/j.jdiacomp.2016.10.030
DO - 10.1016/j.jdiacomp.2016.10.030
M3 - Article
C2 - 27884661
VL - 31
SP - 419
EP - 426
JO - Journal of Diabetes and its Complications
JF - Journal of Diabetes and its Complications
SN - 1056-8727
IS - 2
ER -