Association of late-onset Alzheimer disease with a genotype of PLAU, the gene encoding urokinase-type plasminogen activator on chromosome 10q22.2

U. Finckh, K. Van Hadeln, T. Müller-Thomsen, A. Alberici, G. Binetti, C. Hock, R. M. Nitsch, G. Stoppe, J. Reiss, A. Gal

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Abstract

Urokinase-type plasminogen activator (uPA) converts plasminogen to plasmin. Plasmin is involved in processing of amyloid precursor protein and degrades secreted and aggregated amyloid-β, a hallmark of Alzheimer disease (AD). PLAU, the gene encoding uPA, maps to chromosome 10q22.2 between two regions showing linkage to late-onset AD (LOAD). We genotyped a frequent C/T single nucleotide polymorphism in codon 141 of PLAU (P141L) in 347 patients with LOAD and 291 control subjects, LOAD was associated with homozygous C/C PLAU genotype in the whole sample (χ2=15.7, P=0.00039, df 2), as well as in all sub-samples stratified by gender or APOE ε4 carrier status (χ 2≥ 6.84, P≤0.033, df 2). Odds ratio for LOAD due to homozygosity C/C was 1.89 (95% confidence interval 1.37-2,61). PLAU is a promising new candidate gene for LOAD, with allele C (P141) being a recessive risk allele or allele T (L141) conferring protection.

Original languageEnglish
Pages (from-to)213-217
Number of pages5
JournalNeurogenetics
Volume4
Issue number4
DOIs
Publication statusPublished - Aug 2003

Fingerprint

Urokinase-Type Plasminogen Activator
Alzheimer Disease
Chromosomes
Fibrinolysin
Alleles
Genotype
Genes
Amyloid beta-Protein Precursor
Plasminogen
Amyloid
Codon
Single Nucleotide Polymorphism
Odds Ratio
Confidence Intervals

Keywords

  • Alzheimer disease
  • APOE
  • Plasmin
  • Urokinase gene

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuroscience(all)

Cite this

Association of late-onset Alzheimer disease with a genotype of PLAU, the gene encoding urokinase-type plasminogen activator on chromosome 10q22.2. / Finckh, U.; Van Hadeln, K.; Müller-Thomsen, T.; Alberici, A.; Binetti, G.; Hock, C.; Nitsch, R. M.; Stoppe, G.; Reiss, J.; Gal, A.

In: Neurogenetics, Vol. 4, No. 4, 08.2003, p. 213-217.

Research output: Contribution to journalArticle

Finckh, U, Van Hadeln, K, Müller-Thomsen, T, Alberici, A, Binetti, G, Hock, C, Nitsch, RM, Stoppe, G, Reiss, J & Gal, A 2003, 'Association of late-onset Alzheimer disease with a genotype of PLAU, the gene encoding urokinase-type plasminogen activator on chromosome 10q22.2', Neurogenetics, vol. 4, no. 4, pp. 213-217. https://doi.org/10.1007/s10048-003-0157-9
Finckh, U. ; Van Hadeln, K. ; Müller-Thomsen, T. ; Alberici, A. ; Binetti, G. ; Hock, C. ; Nitsch, R. M. ; Stoppe, G. ; Reiss, J. ; Gal, A. / Association of late-onset Alzheimer disease with a genotype of PLAU, the gene encoding urokinase-type plasminogen activator on chromosome 10q22.2. In: Neurogenetics. 2003 ; Vol. 4, No. 4. pp. 213-217.
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