Association of lipoprotein(a) with atherothrombotic events and fibrinolytic variables. A case-control study

Guido Franceschini, Elisabetta Cofrancesco, Omid Safa, Carla Boschetti, Elena Tremoli, Luciana Mussoni, Cesare R. Sirtori, Michele Cortellaro

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Elevated plasma levels of lipoprotein(a) [Lp(a)] have been associated with an increased risk of cardiovascular disease. The aim of the present study was to investigate whether Lp(a) plasma levels were associated with subsequent ischemic events and with fibrinolytic variables in patients with established atherosclerotic disease enrolled in the prospective PLAT study. Lp(a) levels and fibrinolytic variables in 37 atherosclerotic patients who subsequently developed an atherothrombotic event during the first year of followup (cases) were compared with those in paired controls, matched for age, sex, diagnosis at enrollment and lipid pattern, who remained free from vascular events during the same time frame. Median and mean Lp(a) levels were similar in cases (6.05 mg/dl; 13.8±19.4 mg/dl) and controls (6.05 mg/dl; 17.1±21.6 mg/dl). In the whole group plasma Lp(a) levels correlated significantly with the increase of t-PA antigen (r=0.368; p=0.002) and fibrinolytic activity (r=0.410; p=0.001) induced by venous stasis but not with baseline fibrinolytic variables. These findings indicate that in patients with established atherosclerotic disease Lp(a) may interfere in vivo with the fibrinolytic process but is not predictive of subsequent ischemic events.

Original languageEnglish
Pages (from-to)227-238
Number of pages12
JournalThrombosis Research
Volume78
Issue number3
DOIs
Publication statusPublished - May 1 1995

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Lipoprotein(a)
Case-Control Studies
Blood Vessels
Cardiovascular Diseases
Prospective Studies
Lipids
Antigens

Keywords

  • atherothrombotic events
  • cardiovascular disease
  • fibrinolysis variables
  • Lipoprotein(a)

ASJC Scopus subject areas

  • Hematology
  • Cardiology and Cardiovascular Medicine

Cite this

Association of lipoprotein(a) with atherothrombotic events and fibrinolytic variables. A case-control study. / Franceschini, Guido; Cofrancesco, Elisabetta; Safa, Omid; Boschetti, Carla; Tremoli, Elena; Mussoni, Luciana; Sirtori, Cesare R.; Cortellaro, Michele.

In: Thrombosis Research, Vol. 78, No. 3, 01.05.1995, p. 227-238.

Research output: Contribution to journalArticle

Franceschini, Guido ; Cofrancesco, Elisabetta ; Safa, Omid ; Boschetti, Carla ; Tremoli, Elena ; Mussoni, Luciana ; Sirtori, Cesare R. ; Cortellaro, Michele. / Association of lipoprotein(a) with atherothrombotic events and fibrinolytic variables. A case-control study. In: Thrombosis Research. 1995 ; Vol. 78, No. 3. pp. 227-238.
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