Association of LOXIN, a new functional splicing isoform of the OLR1 gene, with severity and prognostic localization of critical coronary artery stenoses

Alberto Cappelletti, Monica Zanussi, Monica Mazzavillani, Valeria Magni, Giliola Calori, Cosmo Godino, Maurizio Ferrari, Alberto Margonato

Research output: Contribution to journalArticlepeer-review

Abstract

Aims: To evaluate the association between LOXIN, a new functional protective splicing isoform of the oxidized LDL receptor 1 (OLR1) gene, and the severity of coronary artery stenoses. Methods: We analyzed 100 consecutive patients with coronary artery disease (CAD) and 100 controls, all evaluated by a new molecular biology test using highly specific allele primers able to identify the single nucleotide variation (IVS4-14 A>G) in the OLR1 gene (Loxin Test - Technogenetics). All the patients and the controls underwent coronary angiography and, for quantitative evaluation, we used both vessel and stenosis score, and SYNTAX score to evaluate the severity of CAD. Moreover, we defined the prognostic localization of CAD as a critical stenosis (>50%) of the left main and/or proximal segment of left anterior descending artery (LAD). Finally, we evaluated a correlation with the presence of diabetes mellitus, dyslipidemia, hypertension, smoking and family history of CAD. Results: In this selected population, even though the 'AA nonrisk haplotype' is more frequent in the controls, we did not find any statistically significant correlation between the severity of CAD or the prognostic localization of critical stenosis and the difference of IVS4-14 A>G OLR1 genotype (P>0.05). CAD patients showed significantly higher frequencies of dyslipidemia and smoking (P

Original languageEnglish
Pages (from-to)391-396
Number of pages6
JournalJournal of Cardiovascular Medicine
Volume15
Issue number5
DOIs
Publication statusPublished - 2014

Keywords

  • LOXIN test
  • oxidized LDL receptor 1 gene OLR1
  • polymorphism
  • severity and prognostic localization of coronary artery disease

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

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