Association of macroeconomic factors with nonrelapse mortality after allogeneic hematopoietic cell transplantation for adults with acute lymphoblastic leukemia: An analysis from the acute leukemia working party of the EBMT

Sebastian Giebel, Myriam Labopin, Adalberto Ibatici, Paul Browne, Tomasz Czerw, Gerard Socie', Ali Unal, Slawomira Kyrcz-Krzemien, Andrea Bacigalupo, Hakan Goker, Mike Potter, Caroline L. Furness, Grant McQuaker, Dietrich W. Beelen, Noel Milpied, Antonio Victor Campos Coelho, Charles Craddock, Arnon Nagler, Mohamad Mohty

Research output: Contribution to journalArticle

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Abstract

Purpose. From a global perspective, the rates of allogeneic hematopoietic cell transplantation (allo HCT) are closely related to the economicstatus of acountry. However, apotential association with out come has not yet been documented. The goal of this study was to evaluate effects of health care expenditure (HCE), Human Development Index (HDI), team density, and center experience on non relapse mortality (NRM) after HLA-matched sibling alloHCT for adults with acute lymphoblastic leukemia (ALL). Patients and Methods. A total of 983 patients treated with myeloablative alloHCT between 2004 and 2008 in 24 European countries were included. Results. In a univariate analysis, the probability of day 100 NRM was increased for countries with lower current HCE (8% vs. 3%; p = .06), countries with lower HDI (8% vs. 3%; p = .02), and centers with less experience (8% vs. 5%; p = .04). In addition, the overall NRM was increased for countries with lower current HCE (21% vs. 17%; p = .09) and HDI (21% vs. 16%; p = .03) and for centers with lower activity (21%vs.16%;p = .07). Inamultivariate analysis, the strongest predictive model forday100NRMincluded currentHCE greater than the median (hazard ratio [HR], 0.39;p = .002).The overall NRM was mostly predicted by HDI greater than the median (HR, 0.65; p = .01). Both lower current HCE and HDI were associated with decreased probability of overall survival. Conclusion. Both macroeconomic factors and the socioeconomic status of a country strongly influence NRM after alloHCT for adults with ALL. Our findings should be considered when clinical studies in the field of alloHCT are interpreted.

Original languageEnglish
Pages (from-to)377-383
Number of pages7
JournalOncologist
Volume21
Issue number3
DOIs
Publication statusPublished - Feb 11 2016

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Cell Transplantation
Human Development
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Health Expenditures
Leukemia
Economics
Recurrence
Mortality
Delivery of Health Care
Social Class
Siblings
Survival

Keywords

  • Acute lymphoblastic leukemia
  • Health care expenditure
  • Hematopoietic cell transplantation
  • Human development index
  • Non-relapse mortality

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Association of macroeconomic factors with nonrelapse mortality after allogeneic hematopoietic cell transplantation for adults with acute lymphoblastic leukemia : An analysis from the acute leukemia working party of the EBMT. / Giebel, Sebastian; Labopin, Myriam; Ibatici, Adalberto; Browne, Paul; Czerw, Tomasz; Socie', Gerard; Unal, Ali; Kyrcz-Krzemien, Slawomira; Bacigalupo, Andrea; Goker, Hakan; Potter, Mike; Furness, Caroline L.; McQuaker, Grant; Beelen, Dietrich W.; Milpied, Noel; Campos Coelho, Antonio Victor; Craddock, Charles; Nagler, Arnon; Mohty, Mohamad.

In: Oncologist, Vol. 21, No. 3, 11.02.2016, p. 377-383.

Research output: Contribution to journalArticle

Giebel, S, Labopin, M, Ibatici, A, Browne, P, Czerw, T, Socie', G, Unal, A, Kyrcz-Krzemien, S, Bacigalupo, A, Goker, H, Potter, M, Furness, CL, McQuaker, G, Beelen, DW, Milpied, N, Campos Coelho, AV, Craddock, C, Nagler, A & Mohty, M 2016, 'Association of macroeconomic factors with nonrelapse mortality after allogeneic hematopoietic cell transplantation for adults with acute lymphoblastic leukemia: An analysis from the acute leukemia working party of the EBMT', Oncologist, vol. 21, no. 3, pp. 377-383. https://doi.org/10.1634/theoncologist.2015-0314
Giebel, Sebastian ; Labopin, Myriam ; Ibatici, Adalberto ; Browne, Paul ; Czerw, Tomasz ; Socie', Gerard ; Unal, Ali ; Kyrcz-Krzemien, Slawomira ; Bacigalupo, Andrea ; Goker, Hakan ; Potter, Mike ; Furness, Caroline L. ; McQuaker, Grant ; Beelen, Dietrich W. ; Milpied, Noel ; Campos Coelho, Antonio Victor ; Craddock, Charles ; Nagler, Arnon ; Mohty, Mohamad. / Association of macroeconomic factors with nonrelapse mortality after allogeneic hematopoietic cell transplantation for adults with acute lymphoblastic leukemia : An analysis from the acute leukemia working party of the EBMT. In: Oncologist. 2016 ; Vol. 21, No. 3. pp. 377-383.
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AU - Ibatici, Adalberto

AU - Browne, Paul

AU - Czerw, Tomasz

AU - Socie', Gerard

AU - Unal, Ali

AU - Kyrcz-Krzemien, Slawomira

AU - Bacigalupo, Andrea

AU - Goker, Hakan

AU - Potter, Mike

AU - Furness, Caroline L.

AU - McQuaker, Grant

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KW - Non-relapse mortality

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