Association of MBL2 gene exon 1 variants with autoimmune thyroid disease in Brazilian patients

C. B. Filho, F. F. Rodrigues, L. Segat, A. M. Fonseca, J. Araujo, C. Arahata, L. Pontes, L. Vilar, J. L. de Lima Filho, S. Crovella

Research output: Contribution to journalArticlepeer-review

Abstract

We investigated the association between MBL2 gene exon 1 functional polymorphisms and autoimmune thyroid disease (AITD) in 163 Brazilian patients (87 with Hashimoto thyroiditis, HT; 76 with Graves' disease) and 214 healthy controls. Individuals carrying MBL2 O allele are at higher risk of developing AITD (OR=1.58, 95% CI: 1.11-2.26; P-value=0.009) and HT (OR=1.67, 95% CI: 1.09-2.55; P-value=0.013) as suggesting a possible role for mannose-binding lectin in influencing disease susceptibility.

Original languageEnglish
Pages (from-to)357-361
Number of pages5
JournalInternational Journal of Immunogenetics
Volume39
Issue number4
DOIs
Publication statusPublished - Aug 2012

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Immunology
  • Genetics(clinical)

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