Association of metabolic syndrome with carotid thickening and plaque in the general population: A meta-analysis

Cesare Cuspidi, Carla Sala, Marijana Tadic, Elisa Gherbesi, Guido Grassi, Giuseppe Mancia

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We performed a meta-analysis of population studies reporting data on carotid intima-media thickness and plaque in patients with and without metabolic syndrome (MetS) to provide a new piece of information on the relationship of MetS with both phenotypes of vascular damage. The Ovid MEDLINE, PubMed, and Cochrane CENTRAL databases were searched without time restriction up to December 31, 2016. Overall, 19 696 patients (22.2% with MetS) were included in eight studies. Common carotid intima-media thickness was greater in patients with MetS compared with those without it (788 ± 47 μm vs 727 ± 44 μm), with a standard means difference of 0.28 ± 0.06 (P = .00003). Increased intima-media thickness in patients with MetS was paralleled by a higher prevalence of plaques. The present meta-analysis shows that MetS is associated with both ultrasonographic phenotypes of carotid damage. This finding is consistent with the view of MetS as a cluster of hemodynamic and nonhemodynamic factors promoting vascular hypertrophy and plaque.

Original languageEnglish
Pages (from-to)4-10
JournalJournal of Clinical Hypertension
Volume20
Issue number1
DOIs
Publication statusPublished - 2018

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Meta-Analysis
Population
Carotid Intima-Media Thickness
Phenotype
PubMed
MEDLINE
Hypertrophy
Blood Vessels
Research Design
Hemodynamics
Databases

Keywords

  • Carotid intima-media thickness
  • Carotid plaque
  • General population
  • Metabolic syndrome

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine

Cite this

Association of metabolic syndrome with carotid thickening and plaque in the general population : A meta-analysis. / Cuspidi, Cesare; Sala, Carla; Tadic, Marijana; Gherbesi, Elisa; Grassi, Guido; Mancia, Giuseppe.

In: Journal of Clinical Hypertension, Vol. 20, No. 1, 2018, p. 4-10.

Research output: Contribution to journalArticle

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