Abstract
We performed a meta-analysis of population studies reporting data on carotid intima-media thickness and plaque in patients with and without metabolic syndrome (MetS) to provide a new piece of information on the relationship of MetS with both phenotypes of vascular damage. The Ovid MEDLINE, PubMed, and Cochrane CENTRAL databases were searched without time restriction up to December 31, 2016. Overall, 19 696 patients (22.2% with MetS) were included in eight studies. Common carotid intima-media thickness was greater in patients with MetS compared with those without it (788 ± 47 μm vs 727 ± 44 μm), with a standard means difference of 0.28 ± 0.06 (P = .00003). Increased intima-media thickness in patients with MetS was paralleled by a higher prevalence of plaques. The present meta-analysis shows that MetS is associated with both ultrasonographic phenotypes of carotid damage. This finding is consistent with the view of MetS as a cluster of hemodynamic and nonhemodynamic factors promoting vascular hypertrophy and plaque.
| Original language | English |
|---|---|
| Pages (from-to) | 4-10 |
| Journal | Journal of Clinical Hypertension |
| Volume | 20 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2018 |
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Keywords
- Carotid intima-media thickness
- Carotid plaque
- General population
- Metabolic syndrome
ASJC Scopus subject areas
- Internal Medicine
- Endocrinology, Diabetes and Metabolism
- Cardiology and Cardiovascular Medicine
Cite this
Association of metabolic syndrome with carotid thickening and plaque in the general population : A meta-analysis. / Cuspidi, Cesare; Sala, Carla; Tadic, Marijana; Gherbesi, Elisa; Grassi, Guido; Mancia, Giuseppe.
In: Journal of Clinical Hypertension, Vol. 20, No. 1, 2018, p. 4-10.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association of metabolic syndrome with carotid thickening and plaque in the general population
T2 - A meta-analysis
AU - Cuspidi, Cesare
AU - Sala, Carla
AU - Tadic, Marijana
AU - Gherbesi, Elisa
AU - Grassi, Guido
AU - Mancia, Giuseppe
PY - 2018
Y1 - 2018
N2 - We performed a meta-analysis of population studies reporting data on carotid intima-media thickness and plaque in patients with and without metabolic syndrome (MetS) to provide a new piece of information on the relationship of MetS with both phenotypes of vascular damage. The Ovid MEDLINE, PubMed, and Cochrane CENTRAL databases were searched without time restriction up to December 31, 2016. Overall, 19 696 patients (22.2% with MetS) were included in eight studies. Common carotid intima-media thickness was greater in patients with MetS compared with those without it (788 ± 47 μm vs 727 ± 44 μm), with a standard means difference of 0.28 ± 0.06 (P = .00003). Increased intima-media thickness in patients with MetS was paralleled by a higher prevalence of plaques. The present meta-analysis shows that MetS is associated with both ultrasonographic phenotypes of carotid damage. This finding is consistent with the view of MetS as a cluster of hemodynamic and nonhemodynamic factors promoting vascular hypertrophy and plaque.
AB - We performed a meta-analysis of population studies reporting data on carotid intima-media thickness and plaque in patients with and without metabolic syndrome (MetS) to provide a new piece of information on the relationship of MetS with both phenotypes of vascular damage. The Ovid MEDLINE, PubMed, and Cochrane CENTRAL databases were searched without time restriction up to December 31, 2016. Overall, 19 696 patients (22.2% with MetS) were included in eight studies. Common carotid intima-media thickness was greater in patients with MetS compared with those without it (788 ± 47 μm vs 727 ± 44 μm), with a standard means difference of 0.28 ± 0.06 (P = .00003). Increased intima-media thickness in patients with MetS was paralleled by a higher prevalence of plaques. The present meta-analysis shows that MetS is associated with both ultrasonographic phenotypes of carotid damage. This finding is consistent with the view of MetS as a cluster of hemodynamic and nonhemodynamic factors promoting vascular hypertrophy and plaque.
KW - Carotid intima-media thickness
KW - Carotid plaque
KW - General population
KW - Metabolic syndrome
UR - http://www.scopus.com/inward/record.url?scp=85036569434&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85036569434&partnerID=8YFLogxK
U2 - 10.1111/jch.13138
DO - 10.1111/jch.13138
M3 - Article
AN - SCOPUS:85036569434
VL - 20
SP - 4
EP - 10
JO - Journal of clinical hypertension
JF - Journal of clinical hypertension
SN - 1524-6175
IS - 1
ER -