TY - JOUR
T1 - Association of mild anemia with cognitive, functional, mood and quality of life outcomes in the elderly
T2 - The "health and anemia" study
AU - Lucca, Ugo
AU - Tettamanti, Mauro
AU - Mosconi, Paola
AU - Apolone, Giovanni
AU - Gandini, Francesca
AU - Nobili, Alessandro
AU - Tallone, Maria Vittoria
AU - Detoma, Paolo
AU - Giacomin, Adriano
AU - Clerico, Mario
AU - Tempia, Patrizia
AU - Guala, Adriano
AU - Fasolo, Gilberto
AU - Riva, Emma
PY - 2008/4/2
Y1 - 2008/4/2
N2 - Background: In the elderly persons, hemoglobin concentrations slightly below the lower limit of normal are common, but scant evidence is available on their relationship with significant health indicators. The objective of the present study was to cross sectionally investigate the association of mild grade anemia with cognitive, functional, mood, and quality of life (QoL) variables in community-dwelling elderly persons. Methods: Among the 4,068 eligible individuals aged 65-84 years, all persons with mild anemia (n=170) and a randomly selected sample of non-anemic controls (n=547) were included in the study. Anemia was defined according to World Health Organization (WHO) criteria and mild grade anemia was defined as a hemoglobin concentration between 10.0 and 11.9 g/dL in women and between 10.0 and 12.9 g/dL in men. Cognition and functional status were assessed using measures of selective attention, episodic memory, cognitive flexibility and instrumental and basic activities of daily living. Mood and QoL were evaluated by means of the Geriatric Depression Scale-10, the Short-Form health survey (SF-12), and the Functional Assessment of Cancer Therapy Anemia. Results: In univariate analyses, mild anemic elderly persons had significantly worse results on almost all cognitive, functional, mood, and QoL measures. In multivariable logistic regressions, after adjustment for a large number of demographic and clinical confounders, mild anemia remained significantly associated with measures of selective attention and disease specific QoL (all fully adjusted p
AB - Background: In the elderly persons, hemoglobin concentrations slightly below the lower limit of normal are common, but scant evidence is available on their relationship with significant health indicators. The objective of the present study was to cross sectionally investigate the association of mild grade anemia with cognitive, functional, mood, and quality of life (QoL) variables in community-dwelling elderly persons. Methods: Among the 4,068 eligible individuals aged 65-84 years, all persons with mild anemia (n=170) and a randomly selected sample of non-anemic controls (n=547) were included in the study. Anemia was defined according to World Health Organization (WHO) criteria and mild grade anemia was defined as a hemoglobin concentration between 10.0 and 11.9 g/dL in women and between 10.0 and 12.9 g/dL in men. Cognition and functional status were assessed using measures of selective attention, episodic memory, cognitive flexibility and instrumental and basic activities of daily living. Mood and QoL were evaluated by means of the Geriatric Depression Scale-10, the Short-Form health survey (SF-12), and the Functional Assessment of Cancer Therapy Anemia. Results: In univariate analyses, mild anemic elderly persons had significantly worse results on almost all cognitive, functional, mood, and QoL measures. In multivariable logistic regressions, after adjustment for a large number of demographic and clinical confounders, mild anemia remained significantly associated with measures of selective attention and disease specific QoL (all fully adjusted p
UR - http://www.scopus.com/inward/record.url?scp=44849137629&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=44849137629&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0001920
DO - 10.1371/journal.pone.0001920
M3 - Article
C2 - 18382689
AN - SCOPUS:44849137629
VL - 3
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 4
M1 - e1920
ER -