Association of mild anemia with cognitive, functional, mood and quality of life outcomes in the elderly

The "health and anemia" study

Ugo Lucca, Mauro Tettamanti, Paola Mosconi, Giovanni Apolone, Francesca Gandini, Alessandro Nobili, Maria Vittoria Tallone, Paolo Detoma, Adriano Giacomin, Mario Clerico, Patrizia Tempia, Adriano Guala, Gilberto Fasolo, Emma Riva

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

Background: In the elderly persons, hemoglobin concentrations slightly below the lower limit of normal are common, but scant evidence is available on their relationship with significant health indicators. The objective of the present study was to cross sectionally investigate the association of mild grade anemia with cognitive, functional, mood, and quality of life (QoL) variables in community-dwelling elderly persons. Methods: Among the 4,068 eligible individuals aged 65-84 years, all persons with mild anemia (n=170) and a randomly selected sample of non-anemic controls (n=547) were included in the study. Anemia was defined according to World Health Organization (WHO) criteria and mild grade anemia was defined as a hemoglobin concentration between 10.0 and 11.9 g/dL in women and between 10.0 and 12.9 g/dL in men. Cognition and functional status were assessed using measures of selective attention, episodic memory, cognitive flexibility and instrumental and basic activities of daily living. Mood and QoL were evaluated by means of the Geriatric Depression Scale-10, the Short-Form health survey (SF-12), and the Functional Assessment of Cancer Therapy Anemia. Results: In univariate analyses, mild anemic elderly persons had significantly worse results on almost all cognitive, functional, mood, and QoL measures. In multivariable logistic regressions, after adjustment for a large number of demographic and clinical confounders, mild anemia remained significantly associated with measures of selective attention and disease specific QoL (all fully adjusted p

Original languageEnglish
Article numbere1920
JournalPLoS One
Volume3
Issue number4
DOIs
Publication statusPublished - Apr 2 2008

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emotions
quality of life
anemia
Anemia
Hemoglobins
Functional assessment
Geriatrics
Quality of Life
Health
Logistics
hemoglobin
functional status
Data storage equipment
World Health Organization
cognition
Independent Living
demographic statistics
Episodic Memory
Activities of Daily Living
Health Surveys

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Association of mild anemia with cognitive, functional, mood and quality of life outcomes in the elderly : The "health and anemia" study. / Lucca, Ugo; Tettamanti, Mauro; Mosconi, Paola; Apolone, Giovanni; Gandini, Francesca; Nobili, Alessandro; Tallone, Maria Vittoria; Detoma, Paolo; Giacomin, Adriano; Clerico, Mario; Tempia, Patrizia; Guala, Adriano; Fasolo, Gilberto; Riva, Emma.

In: PLoS One, Vol. 3, No. 4, e1920, 02.04.2008.

Research output: Contribution to journalArticle

Lucca, Ugo ; Tettamanti, Mauro ; Mosconi, Paola ; Apolone, Giovanni ; Gandini, Francesca ; Nobili, Alessandro ; Tallone, Maria Vittoria ; Detoma, Paolo ; Giacomin, Adriano ; Clerico, Mario ; Tempia, Patrizia ; Guala, Adriano ; Fasolo, Gilberto ; Riva, Emma. / Association of mild anemia with cognitive, functional, mood and quality of life outcomes in the elderly : The "health and anemia" study. In: PLoS One. 2008 ; Vol. 3, No. 4.
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