Association of MT1A haplotype with cardiovascular disease and antioxidant enzyme defense in elderly Greek population

Comparison with an Italian cohort

Robertina Giacconi, Stavroula Kanoni, Patrizia Mecocci, Marco Malavolta, Dimitris Richter, Sara Pierpaoli, Laura Costarelli, Catia Cipriano, Elisa Muti, Francesca Mangialasche, Francesco Piacenza, Silvia Tesei, Roberta Galeazzi, Eirini V. Theodoraki, Fabrizia Lattanzio, George Dedoussis, Eugenio Mocchegiani

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Metallothioneins (MT), the antioxidant zinc-binding proteins, seem to mediate cardioprotection. It has been postulated that zinc homeostasis and MT function may be altered, as a consequence of oxidative stress, in cardiovascular disease (CVD), with a potential implication of MT genetic polymorphisms. The present study explores the role of +647A/C and +1245A/G MT1A polymorphisms on the susceptibility to CVD, zinc status and enzyme antioxidant activity, in the Greek and Italian populations. The country selection was based on the lower zinc status and the reduced zinc dietary intake in Greece than in Italy despite the similar Mediterranean dietary pattern. A total of 464 old, healthy control subjects and 369 old CVD patients more than 70 years of age were studied. Logistic regression model indicated that +1245 MT1A G+ genotype significantly increased the risk of CVD in Greece (34.4% vs 23.2%; odds ratio=1.88, 95% confidence interval=1.14-3.08; P=013) but not in Italy. Haplotype analysis showed an increment of CG haplotype frequency in CVD Greek patients (17.4% vs. 10.6%, P

Original languageEnglish
Pages (from-to)1008-1014
Number of pages7
JournalJournal of Nutritional Biochemistry
Volume21
Issue number10
DOIs
Publication statusPublished - Oct 2010

Fingerprint

Haplotypes
Cardiovascular Diseases
Antioxidants
Zinc
Metallothionein
Enzymes
Population
Greece
Polymorphism
Italy
Logistic Models
Oxidative stress
Genetic Polymorphisms
Logistics
Healthy Volunteers
Oxidative Stress
Homeostasis
Odds Ratio
Genotype
Confidence Intervals

Keywords

  • Cardiovascular disease
  • Enzyme antioxidant activity
  • Metallothionein polymorphisms
  • Zinc

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Molecular Biology
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Association of MT1A haplotype with cardiovascular disease and antioxidant enzyme defense in elderly Greek population : Comparison with an Italian cohort. / Giacconi, Robertina; Kanoni, Stavroula; Mecocci, Patrizia; Malavolta, Marco; Richter, Dimitris; Pierpaoli, Sara; Costarelli, Laura; Cipriano, Catia; Muti, Elisa; Mangialasche, Francesca; Piacenza, Francesco; Tesei, Silvia; Galeazzi, Roberta; Theodoraki, Eirini V.; Lattanzio, Fabrizia; Dedoussis, George; Mocchegiani, Eugenio.

In: Journal of Nutritional Biochemistry, Vol. 21, No. 10, 10.2010, p. 1008-1014.

Research output: Contribution to journalArticle

Giacconi, Robertina ; Kanoni, Stavroula ; Mecocci, Patrizia ; Malavolta, Marco ; Richter, Dimitris ; Pierpaoli, Sara ; Costarelli, Laura ; Cipriano, Catia ; Muti, Elisa ; Mangialasche, Francesca ; Piacenza, Francesco ; Tesei, Silvia ; Galeazzi, Roberta ; Theodoraki, Eirini V. ; Lattanzio, Fabrizia ; Dedoussis, George ; Mocchegiani, Eugenio. / Association of MT1A haplotype with cardiovascular disease and antioxidant enzyme defense in elderly Greek population : Comparison with an Italian cohort. In: Journal of Nutritional Biochemistry. 2010 ; Vol. 21, No. 10. pp. 1008-1014.
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