TY - JOUR
T1 - Association of neovascular age-related macular degeneration with month and season of birth in Italy
AU - Longo, Antonio
AU - Casuccio, Alessandra
AU - Pani, Luca
AU - Avitabile, Teresio
AU - Cillino, Salvatore
AU - Uva, Maurizio G.
AU - Bonfiglio, Vincenza
AU - Russo, Andrea
AU - Parisi, Guglielmo
AU - Cennamo, Gilda
AU - Furino, Claudio
AU - Parravano, Mariacristina
AU - Xoxi, Entela
AU - Reibaldi, Michele
PY - 2016/12/19
Y1 - 2016/12/19
N2 - In order to investigate the influence of season and month of birth on the risk of neovascular age-related macular degeneration (n-AMD) in Italy, we evaluated the month birth and sex of all patients, recorded in the anti-vascular endothelial growth factor (VEGF) monitoring registry of the Italian Medicines Agency, born between 1925-1944, who received intravitreal anti-VEGF injections for n-AMD between January 1, 2013 and July 29, 2015. The numbers of all births in Italy in the same years, extracted from the Italian National Institute of Statistics, were used to calculate the expected number of n-AMD cases. Overall, 45,845 patients (19,207 men, 26,638 women) received intravitreal anti-VEGF for n-AMD; in the same years, 20,140,426 people (10,334,262 male, 9,806,164 female) were born in Italy. Comparing the observed number of n-AMD cases with the expected number of n- AMD cases in each season, we found that the season-specific risk for n-AMD was 2.5% higher for those born in summer (OR=1.03, Bonferroni-corrected P=0.008) and 3% lower for those born in winter (OR=0.96, Bonferroni-corrected P=0.0004). When considering the month of birth, the risk of n-AMD was 5.9% lower for people born in January (OR=0.93, Bonferroni-corrected P=0.0012). The factors causing such differences should be determined.
AB - In order to investigate the influence of season and month of birth on the risk of neovascular age-related macular degeneration (n-AMD) in Italy, we evaluated the month birth and sex of all patients, recorded in the anti-vascular endothelial growth factor (VEGF) monitoring registry of the Italian Medicines Agency, born between 1925-1944, who received intravitreal anti-VEGF injections for n-AMD between January 1, 2013 and July 29, 2015. The numbers of all births in Italy in the same years, extracted from the Italian National Institute of Statistics, were used to calculate the expected number of n-AMD cases. Overall, 45,845 patients (19,207 men, 26,638 women) received intravitreal anti-VEGF for n-AMD; in the same years, 20,140,426 people (10,334,262 male, 9,806,164 female) were born in Italy. Comparing the observed number of n-AMD cases with the expected number of n- AMD cases in each season, we found that the season-specific risk for n-AMD was 2.5% higher for those born in summer (OR=1.03, Bonferroni-corrected P=0.008) and 3% lower for those born in winter (OR=0.96, Bonferroni-corrected P=0.0004). When considering the month of birth, the risk of n-AMD was 5.9% lower for people born in January (OR=0.93, Bonferroni-corrected P=0.0012). The factors causing such differences should be determined.
KW - Anti-VEGF
KW - Month of birth
KW - Neovascular age-related macular degeneration
KW - Neovascular AMD
KW - Season of birth
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U2 - 10.18632/aging.101137
DO - 10.18632/aging.101137
M3 - Article
AN - SCOPUS:85013361046
VL - 9
SP - 133
EP - 141
JO - Aging
JF - Aging
SN - 1945-4589
IS - 1
ER -