Association of neutrophil and complement defects in two twins with Shwachman syndrome

F. Sacchi, G. Maggiore, G. Marseglia, M. Marconi, L. Nespoli, A. G. Siccardi

Research output: Contribution to journalArticle

Abstract

Immunological functions were studied in two 22-month-old dizygotic twins with the characteristic features of Shwachman syndrome. A severe defect of neutrophil motility was found in both children, but not in their parents. An impairment of the activity of the alternative pathway of complement was present in the sera of both patients. This defect, in association with the neutropenia and the chemotactic defect, might be related to the recurrent infections displayed by the twins.

Original languageEnglish
Pages (from-to)177-181
Number of pages5
JournalHelvetica Paediatrica Acta
Volume37
Issue number2
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Fingerprint Dive into the research topics of 'Association of neutrophil and complement defects in two twins with Shwachman syndrome'. Together they form a unique fingerprint.

  • Cite this

    Sacchi, F., Maggiore, G., Marseglia, G., Marconi, M., Nespoli, L., & Siccardi, A. G. (1982). Association of neutrophil and complement defects in two twins with Shwachman syndrome. Helvetica Paediatrica Acta, 37(2), 177-181.