Association of NK-cell lymphoproliferative disease and nephrotic syndrome

R. Bassan, A. Rambaldi, M. Abbate, A. Biondi, P. Allavena, T. Barbui, T. Bertani

Research output: Contribution to journalArticlepeer-review


A 56-year-old white man with a seven-year history of lymphocytosis of large granular lymphocytes (LGL) developed mild renal insufficiency (serum creatinine 150 μmol/L (1.7 mg/dL) with proteinuria (3.4 g/day). Laboratory investigations confirmed a proliferative disease of non-T lineage cytotoxic LGL/natural killer (NK) cells, and the renal biopsy documented focal and segmental glomerulosclerosis associated with interstitial inflammation and tubular atrophy. These findings could be explained by production and release of humoral mediators by pathologic LGL/NK cells. The renal function must be carefully monitored in patients with LGL/NK proliferative disorders, and the role of the NK cell system in renal diseases should be investigated.

Original languageEnglish
Pages (from-to)334-338
Number of pages5
JournalAmerican Journal of Clinical Pathology
Issue number3
Publication statusPublished - 1990


  • cells
  • nephrotic syndrome
  • NK
  • proliferation

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


Dive into the research topics of 'Association of NK-cell lymphoproliferative disease and nephrotic syndrome'. Together they form a unique fingerprint.

Cite this