TY - JOUR
T1 - Association of obesity and central fat distribution with carotid artery wall thickening in middle-aged women
AU - De Michele, Mario
AU - Panico, Salvatore
AU - Iannuzzi, Arcangelo
AU - Celentano, Egidio
AU - Ciardullo, Anna V.
AU - Galasso, Rocco
AU - Sacchetti, Lucia
AU - Zarrilli, Federica
AU - Bond, M. Gene
AU - Rubba, Paolo
PY - 2002/12/1
Y1 - 2002/12/1
N2 - Background and Purpose - The association between obesity and atherosclerotic disease is controversial. In the present analysis, we evaluated whether common carotid intima-media thickness (IMT) and area, 2 markers of preclinical atherosclerosis, were increased in obese subjects. Methods - More than 5000 middle-aged women (n=5062; age, 30 to 69 years) living in the area of Naples, Southern Italy, were recruited for a prospective, currently ongoing study on the etiology of cardiovascular disease and cancer in the female population (the Progetto ATENA study). A subsample of 310 participants underwent high-resolution B-mode ultrasound examination, and the IMTs, intima-media areas, and lumen diameters of common carotid arteries were measured with a semiautomated computerized program. Subjects were divided into 3 groups on the basis of the recently published obesity guidelines for body mass index (BMI), a marker of general obesity, and tertiles of waist-to-hip ratio (WHR), a marker of regional obesity. Results - Women with a BMI ≥30 kg/m2 showed higher systolic and diastolic blood pressures, triglycerides, and fasting glucose and insulin, as well as lower high-density lipoprotein concentrations, than subjects with lower BMI. A gradual increase in common carotid IMT and intima-media area was observed when lean women (0.94±0.01 mm and 19.8±0.5 mm2, respectively) were compared with overweight (0.98±0.01 mm and 21.0±0.4 mm2) and obese (1.02±0.02 mm and 22.6±0.8 mm2, P0.85) had adverse risk factor profiles and thicker carotid intima-media complex than those in the first 2 tertiles (P
AB - Background and Purpose - The association between obesity and atherosclerotic disease is controversial. In the present analysis, we evaluated whether common carotid intima-media thickness (IMT) and area, 2 markers of preclinical atherosclerosis, were increased in obese subjects. Methods - More than 5000 middle-aged women (n=5062; age, 30 to 69 years) living in the area of Naples, Southern Italy, were recruited for a prospective, currently ongoing study on the etiology of cardiovascular disease and cancer in the female population (the Progetto ATENA study). A subsample of 310 participants underwent high-resolution B-mode ultrasound examination, and the IMTs, intima-media areas, and lumen diameters of common carotid arteries were measured with a semiautomated computerized program. Subjects were divided into 3 groups on the basis of the recently published obesity guidelines for body mass index (BMI), a marker of general obesity, and tertiles of waist-to-hip ratio (WHR), a marker of regional obesity. Results - Women with a BMI ≥30 kg/m2 showed higher systolic and diastolic blood pressures, triglycerides, and fasting glucose and insulin, as well as lower high-density lipoprotein concentrations, than subjects with lower BMI. A gradual increase in common carotid IMT and intima-media area was observed when lean women (0.94±0.01 mm and 19.8±0.5 mm2, respectively) were compared with overweight (0.98±0.01 mm and 21.0±0.4 mm2) and obese (1.02±0.02 mm and 22.6±0.8 mm2, P0.85) had adverse risk factor profiles and thicker carotid intima-media complex than those in the first 2 tertiles (P
KW - Atherosclerosis
KW - Carotid arteries
KW - Obesity
KW - Women
UR - http://www.scopus.com/inward/record.url?scp=0036905132&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036905132&partnerID=8YFLogxK
U2 - 10.1161/01.STR.0000038989.90931.BE
DO - 10.1161/01.STR.0000038989.90931.BE
M3 - Article
C2 - 12468792
AN - SCOPUS:0036905132
VL - 33
SP - 2923
EP - 2928
JO - Stroke
JF - Stroke
SN - 0039-2499
IS - 12
ER -