Association of obesity and central fat distribution with carotid artery wall thickening in middle-aged women

Mario De Michele, Salvatore Panico, Arcangelo Iannuzzi, Egidio Celentano, Anna V. Ciardullo, Rocco Galasso, Lucia Sacchetti, Federica Zarrilli, M. Gene Bond, Paolo Rubba

Research output: Contribution to journalArticle

156 Citations (Scopus)

Abstract

Background and Purpose - The association between obesity and atherosclerotic disease is controversial. In the present analysis, we evaluated whether common carotid intima-media thickness (IMT) and area, 2 markers of preclinical atherosclerosis, were increased in obese subjects. Methods - More than 5000 middle-aged women (n=5062; age, 30 to 69 years) living in the area of Naples, Southern Italy, were recruited for a prospective, currently ongoing study on the etiology of cardiovascular disease and cancer in the female population (the Progetto ATENA study). A subsample of 310 participants underwent high-resolution B-mode ultrasound examination, and the IMTs, intima-media areas, and lumen diameters of common carotid arteries were measured with a semiautomated computerized program. Subjects were divided into 3 groups on the basis of the recently published obesity guidelines for body mass index (BMI), a marker of general obesity, and tertiles of waist-to-hip ratio (WHR), a marker of regional obesity. Results - Women with a BMI ≥30 kg/m2 showed higher systolic and diastolic blood pressures, triglycerides, and fasting glucose and insulin, as well as lower high-density lipoprotein concentrations, than subjects with lower BMI. A gradual increase in common carotid IMT and intima-media area was observed when lean women (0.94±0.01 mm and 19.8±0.5 mm2, respectively) were compared with overweight (0.98±0.01 mm and 21.0±0.4 mm2) and obese (1.02±0.02 mm and 22.6±0.8 mm2, P0.85) had adverse risk factor profiles and thicker carotid intima-media complex than those in the first 2 tertiles (P

Original languageEnglish
Pages (from-to)2923-2928
Number of pages6
JournalStroke
Volume33
Issue number12
DOIs
Publication statusPublished - Dec 1 2002

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Abdominal Obesity
Carotid Arteries
Obesity
Fats
Carotid Intima-Media Thickness
Body Mass Index
Blood Pressure
Waist-Hip Ratio
Common Carotid Artery
HDL Lipoproteins
Italy
Fasting
Atherosclerosis
Triglycerides
Cardiovascular Diseases
Guidelines
Insulin
Glucose
Population
Neoplasms

Keywords

  • Atherosclerosis
  • Carotid arteries
  • Obesity
  • Women

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

Cite this

De Michele, M., Panico, S., Iannuzzi, A., Celentano, E., Ciardullo, A. V., Galasso, R., ... Rubba, P. (2002). Association of obesity and central fat distribution with carotid artery wall thickening in middle-aged women. Stroke, 33(12), 2923-2928. https://doi.org/10.1161/01.STR.0000038989.90931.BE

Association of obesity and central fat distribution with carotid artery wall thickening in middle-aged women. / De Michele, Mario; Panico, Salvatore; Iannuzzi, Arcangelo; Celentano, Egidio; Ciardullo, Anna V.; Galasso, Rocco; Sacchetti, Lucia; Zarrilli, Federica; Bond, M. Gene; Rubba, Paolo.

In: Stroke, Vol. 33, No. 12, 01.12.2002, p. 2923-2928.

Research output: Contribution to journalArticle

De Michele, M, Panico, S, Iannuzzi, A, Celentano, E, Ciardullo, AV, Galasso, R, Sacchetti, L, Zarrilli, F, Bond, MG & Rubba, P 2002, 'Association of obesity and central fat distribution with carotid artery wall thickening in middle-aged women', Stroke, vol. 33, no. 12, pp. 2923-2928. https://doi.org/10.1161/01.STR.0000038989.90931.BE
De Michele, Mario ; Panico, Salvatore ; Iannuzzi, Arcangelo ; Celentano, Egidio ; Ciardullo, Anna V. ; Galasso, Rocco ; Sacchetti, Lucia ; Zarrilli, Federica ; Bond, M. Gene ; Rubba, Paolo. / Association of obesity and central fat distribution with carotid artery wall thickening in middle-aged women. In: Stroke. 2002 ; Vol. 33, No. 12. pp. 2923-2928.
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AU - Galasso, Rocco

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