Association of pesticide exposure, vaccination response, and interleukin-1 gene polymorphisms

M. Baranska, L. Van Amelsvoort, S. Birindelli, S. Fustinoni, E. Corsini, J. Liesivuori, H. Van Loveren

Research output: Contribution to journalArticle


We performed a cross-sectional study involving workers from four European countries in which exposure to pesticides and immune parameters were evaluated over a short period of time. The total study population consisted of 238 workers occupationally exposed to pesticides and 198 nonoccupationally exposed workers. The study showed that pesticide exposure at levels encountered by workers under different conditions in Europe did not affect the ability of the immune system to respond to vaccination. We could, however, identify individuals within the group of pesticide exposed workers who were genetically characterized by the 2.2 IL-1± polymorphism and who showed a lower antibody response, pointing out the importance of the understanding of genetic variability and the interaction between genetic and environmental factors in the identification of high-risk individuals, which may eventually lead to preventive measures.

Original languageEnglish
Pages (from-to)709-713
Number of pages5
JournalHuman and Experimental Toxicology
Issue number9
Publication statusPublished - Sep 2008



  • Cross-sectional
  • EPI study
  • Genetics
  • Immuno suppression
  • Immunotoxicity

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Baranska, M., Van Amelsvoort, L., Birindelli, S., Fustinoni, S., Corsini, E., Liesivuori, J., & Van Loveren, H. (2008). Association of pesticide exposure, vaccination response, and interleukin-1 gene polymorphisms. Human and Experimental Toxicology, 27(9), 709-713.