Association of PLA2 polymorphism of the ITGB3 gene with early fetal loss

Laura Ruzzi, Iolanda Ciarafoni, Lorena Silvestri, Maria Letizia Semeraro, Damiano Abeni

Research output: Contribution to journalArticle

Abstract

To study the association between early fetal loss and the presence of the PLA2 polymorphism of the ITGB3 gene we conducted a case-control study on 98 cases (i.e., women in fertile age, who experienced at least one episode of early fetal loss) and 38 healthy controls. PLA2 polymorphism was present in 44.2% of cases and 18.4% of controls, and cases with one (n = 24) event had an odds ratio (OR) = 2.7 (95% confidence interval [CI] 0.7-10.0), with two events (n = 52) an OR = 3.8 (95% CI 1.3-11.5), and with three (n = 16) or four abortions (n = 6) had a combined OR = 4.4 (95% CI 1.2-17.0), compared to controls, indicating that PLA2 polymorphism may be implicated in an inherited form of thrombophilia, and to early fetal loss.

Original languageEnglish
Pages (from-to)511-512
Number of pages2
JournalFertility and Sterility
Volume83
Issue number2
DOIs
Publication statusPublished - Feb 2005

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Odds Ratio
Confidence Intervals
Genes
Thrombophilia
Case-Control Studies

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Association of PLA2 polymorphism of the ITGB3 gene with early fetal loss. / Ruzzi, Laura; Ciarafoni, Iolanda; Silvestri, Lorena; Semeraro, Maria Letizia; Abeni, Damiano.

In: Fertility and Sterility, Vol. 83, No. 2, 02.2005, p. 511-512.

Research output: Contribution to journalArticle

Ruzzi, Laura ; Ciarafoni, Iolanda ; Silvestri, Lorena ; Semeraro, Maria Letizia ; Abeni, Damiano. / Association of PLA2 polymorphism of the ITGB3 gene with early fetal loss. In: Fertility and Sterility. 2005 ; Vol. 83, No. 2. pp. 511-512.
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