TY - JOUR
T1 - Association of plasma eotaxin levels with the presence and extent of angiographic coronary artery disease
AU - Emanuele, Enzo
AU - Falcone, Colomba
AU - D'Angelo, Angela
AU - Minoretti, Piercarlo
AU - Buzzi, Maria P.
AU - Bertona, Marco
AU - Geroldi, Diego
PY - 2006/5
Y1 - 2006/5
N2 - Eotaxin (CCL11) is an eosinophil-specific chemoattractant which has been found to be highly expressed at sites of vascular pathology. In the present study, we aimed to evaluate the association of plasma eotaxin levels with the presence and extent of angiographic coronary artery disease (CAD). Three hundred and fifty six consecutive patients attending for elective coronary angiography were investigated. Compared with 111 patients without CAD, 245 with CAD showed higher eotaxin concentrations [median (interquartile range): 76.0 (56.3-103.0) pg/ml versus 116.0 (80.5-162.0) pg/ml, respectively; P <0.001]. Importantly, a significant Spearman correlation was found between eotaxin levels and the extent score of coronary artery stenosis (r = 0.449, P <0.001). A stepwise increase in plasma levels of eotaxin was also found depending on the number of >50% coronary stenosis: median value 76.0 pg/ml in CAD(-) subjects, 96.0 pg/ml in 1-vessel disease, 128.0 pg/ml in 2-vessel disease, and 129.0 pg/ml in 3-vessel disease (P <0.001 for trend). After confounding variables were controlled for, multiple stepwise regression analysis demonstrated that plasma eotaxin was an independent predictor of angiographic extent of CAD (β = 0.426, P <0.001). Our data suggest that increased eotaxin levels are associated with the presence of CAD and that circulating levels of this chemokine may reflect the extent of coronary atherosclerosis.
AB - Eotaxin (CCL11) is an eosinophil-specific chemoattractant which has been found to be highly expressed at sites of vascular pathology. In the present study, we aimed to evaluate the association of plasma eotaxin levels with the presence and extent of angiographic coronary artery disease (CAD). Three hundred and fifty six consecutive patients attending for elective coronary angiography were investigated. Compared with 111 patients without CAD, 245 with CAD showed higher eotaxin concentrations [median (interquartile range): 76.0 (56.3-103.0) pg/ml versus 116.0 (80.5-162.0) pg/ml, respectively; P <0.001]. Importantly, a significant Spearman correlation was found between eotaxin levels and the extent score of coronary artery stenosis (r = 0.449, P <0.001). A stepwise increase in plasma levels of eotaxin was also found depending on the number of >50% coronary stenosis: median value 76.0 pg/ml in CAD(-) subjects, 96.0 pg/ml in 1-vessel disease, 128.0 pg/ml in 2-vessel disease, and 129.0 pg/ml in 3-vessel disease (P <0.001 for trend). After confounding variables were controlled for, multiple stepwise regression analysis demonstrated that plasma eotaxin was an independent predictor of angiographic extent of CAD (β = 0.426, P <0.001). Our data suggest that increased eotaxin levels are associated with the presence of CAD and that circulating levels of this chemokine may reflect the extent of coronary atherosclerosis.
KW - Angiography
KW - Coronary artery disease
KW - Eotaxin
KW - Stenosis
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U2 - 10.1016/j.atherosclerosis.2005.07.002
DO - 10.1016/j.atherosclerosis.2005.07.002
M3 - Article
C2 - 16084515
AN - SCOPUS:33645867979
VL - 186
SP - 140
EP - 145
JO - Atherosclerosis
JF - Atherosclerosis
SN - 0021-9150
IS - 1
ER -