Association of polyps with early-onset colorectal cancer and throughout surveillance: novel clinical and molecular implications

José Perea García, Julia Arribas, Ángel Cañete, Juan Luis García, Edurne Álvaro, Sandra Tapial, Cristina Narváez, Alfredo Vivas, Lorena Brandáriz, Sergio Hernández-Villafranca, Daniel Rueda, Yolanda Rodríguez, Jessica Pérez-García, Susana Olmedillas-López, Damián García-Olmo, Giulia Martina Cavestro, Miguel Urioste, Ajay Goel, Rogelio González-Sarmiento

Research output: Contribution to journalArticlepeer-review

Abstract

Early-onset colorectal cancer (EOCRC) is an increasing and worrisome entity. The aim of this study was to analyze its association with polyps concerning prognosis and surveillance. EOCRC cases were compared regarding the presence or absence of associated polyps (clinical and molecular features), during a minimum of 7 years of follow-up. Of 119 cases, 56 (47%) did not develop polyps (NP group), while 63 (53%) did (P group). The NP group showed a predominant location of the CRC in the rectum (50%), of sporadic cases (54%), and diagnosis at advanced stages: Only P53 and SMARCB1 mutations were statistically linked to this group. The P group, including mainly early-diagnosed tumors, was linked with the most frequent and differential altered chromosomal regions in the array comparative genomic hybridization. The two most frequent groups according to the follow-up were the NP group (40%), and patients developing polyps in the first 5 years of follow-up (P < 5FU) (34%) (these last groups predominantly diagnosed at the earliest stage and with adenomatous polyps (45%)). EOCRC with polyps that developed during the entire follow-up (PDFU group) were mainly located in the right colon (53%), diagnosed in earlier stages, and 75% had a familial history of CRC. Patients developing polyps after the first 5 years (P > 5FU) showed a mucinous component (50%). Our results show that the absence or presence of polyps in EOCRC is an important prognostic factor with differential phenotypes. The development of polyps during surveillance shows that it is necessary to extend the follow-up time, also in those cases with microsatellite-stable EOCRC.

Original languageEnglish
Article number1900
JournalCancers
Volume11
Issue number12
DOIs
Publication statusPublished - Dec 2019

Keywords

  • Early-onset colorectal cancer
  • Follow-up
  • Polyp development
  • Prognosis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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