TY - JOUR
T1 - Association of polyps with early-onset colorectal cancer and throughout surveillance
T2 - novel clinical and molecular implications
AU - García, José Perea
AU - Arribas, Julia
AU - Cañete, Ángel
AU - García, Juan Luis
AU - Álvaro, Edurne
AU - Tapial, Sandra
AU - Narváez, Cristina
AU - Vivas, Alfredo
AU - Brandáriz, Lorena
AU - Hernández-Villafranca, Sergio
AU - Rueda, Daniel
AU - Rodríguez, Yolanda
AU - Pérez-García, Jessica
AU - Olmedillas-López, Susana
AU - García-Olmo, Damián
AU - Cavestro, Giulia Martina
AU - Urioste, Miguel
AU - Goel, Ajay
AU - González-Sarmiento, Rogelio
PY - 2019/12
Y1 - 2019/12
N2 - Early-onset colorectal cancer (EOCRC) is an increasing and worrisome entity. The aim of this study was to analyze its association with polyps concerning prognosis and surveillance. EOCRC cases were compared regarding the presence or absence of associated polyps (clinical and molecular features), during a minimum of 7 years of follow-up. Of 119 cases, 56 (47%) did not develop polyps (NP group), while 63 (53%) did (P group). The NP group showed a predominant location of the CRC in the rectum (50%), of sporadic cases (54%), and diagnosis at advanced stages: Only P53 and SMARCB1 mutations were statistically linked to this group. The P group, including mainly early-diagnosed tumors, was linked with the most frequent and differential altered chromosomal regions in the array comparative genomic hybridization. The two most frequent groups according to the follow-up were the NP group (40%), and patients developing polyps in the first 5 years of follow-up (P < 5FU) (34%) (these last groups predominantly diagnosed at the earliest stage and with adenomatous polyps (45%)). EOCRC with polyps that developed during the entire follow-up (PDFU group) were mainly located in the right colon (53%), diagnosed in earlier stages, and 75% had a familial history of CRC. Patients developing polyps after the first 5 years (P > 5FU) showed a mucinous component (50%). Our results show that the absence or presence of polyps in EOCRC is an important prognostic factor with differential phenotypes. The development of polyps during surveillance shows that it is necessary to extend the follow-up time, also in those cases with microsatellite-stable EOCRC.
AB - Early-onset colorectal cancer (EOCRC) is an increasing and worrisome entity. The aim of this study was to analyze its association with polyps concerning prognosis and surveillance. EOCRC cases were compared regarding the presence or absence of associated polyps (clinical and molecular features), during a minimum of 7 years of follow-up. Of 119 cases, 56 (47%) did not develop polyps (NP group), while 63 (53%) did (P group). The NP group showed a predominant location of the CRC in the rectum (50%), of sporadic cases (54%), and diagnosis at advanced stages: Only P53 and SMARCB1 mutations were statistically linked to this group. The P group, including mainly early-diagnosed tumors, was linked with the most frequent and differential altered chromosomal regions in the array comparative genomic hybridization. The two most frequent groups according to the follow-up were the NP group (40%), and patients developing polyps in the first 5 years of follow-up (P < 5FU) (34%) (these last groups predominantly diagnosed at the earliest stage and with adenomatous polyps (45%)). EOCRC with polyps that developed during the entire follow-up (PDFU group) were mainly located in the right colon (53%), diagnosed in earlier stages, and 75% had a familial history of CRC. Patients developing polyps after the first 5 years (P > 5FU) showed a mucinous component (50%). Our results show that the absence or presence of polyps in EOCRC is an important prognostic factor with differential phenotypes. The development of polyps during surveillance shows that it is necessary to extend the follow-up time, also in those cases with microsatellite-stable EOCRC.
KW - Early-onset colorectal cancer
KW - Follow-up
KW - Polyp development
KW - Prognosis
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UR - http://www.scopus.com/inward/citedby.url?scp=85075925827&partnerID=8YFLogxK
U2 - 10.3390/cancers11121900
DO - 10.3390/cancers11121900
M3 - Article
AN - SCOPUS:85075925827
VL - 11
JO - Cancers
JF - Cancers
SN - 2072-6694
IS - 12
M1 - 1900
ER -