Association of portal venous system thrombosis with endoscopic variceal treatment: A systematic review and meta-analysis

Le Wang, Xiaozhong Guo, Xiangbo Xu, Cyriac Abby Philips, Massimo Primignani, Nahum Mendez-Sanchez, Qianqian Li, Kexin Zheng, Xingshun Qi

Research output: Contribution to journalReview articlepeer-review

Abstract

The association of endoscopic variceal treatment (EVT) with the development of portal venous system thrombosis (PVST) in liver cirrhosis remains uncertain. A systematic review and meta-analysis aimed to investigate the incidence of PVST after EVT and to explore the association of EVT with the development of PVST in liver cirrhosis. All relevant studies were searched via the PubMed, EMBASE, and Cochrane Library databases. The incidence of PVST in patients treated with and without EVT was pooled. Risk ratios with 95% confidence intervals (CIs) were calculated. Heterogeneity among studies was calculated. Meta-regression, sensitivity, and subgroup analyses were used to analyze the source of heterogeneity. Thirteen studies involving a total of 833 patients were included. The pooled incidence of PVST after EVT was 10.4% (95% CI, 4.9-17.7%). There was a statistically significant heterogeneity (I2 = 83.3%, P < 0.0001). Meta-regression, sensitivity, and subgroup analyses did not find the source of heterogeneity. Four studies compared the incidence of PVST between patients treated with and without EVT. The incidence of PVST was significantly higher in the EVT group than that in the no-EVT group (risk ratio: 2.23; 95% CI, 1.11-4.49; P = 0.02). The heterogeneity was not statistically significant (I2= 0%, P = 0.43). In conclusion, PVST after EVT may not be scare, and EVT may increase the risk of PVST in liver cirrhosis.

Original languageEnglish
Pages (from-to)125-131
Number of pages7
JournalEuropean Journal of Gastroenterology and Hepatology
DOIs
Publication statusAccepted/In press - 2021

Keywords

  • endoscopic
  • liver cirrhosis
  • meta-analysis
  • portal hypertension
  • portal vein thrombosis
  • risk
  • systematic review
  • variceal

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Fingerprint

Dive into the research topics of 'Association of portal venous system thrombosis with endoscopic variceal treatment: A systematic review and meta-analysis'. Together they form a unique fingerprint.

Cite this