Association of programmed death ligand-1 (PD-L1) expression with treatment outcomes in patients with BRAF mutation-positive melanoma treated with vemurafenib or cobimetinib combined with vemurafenib

Matthew J Wongchenko; Antoni Ribas; Brigitte Dréno; Paolo A Ascierto; Grant A McArthur; Jorge D Gallo; Isabelle A Rooney; Jessie Hsu; Hartmut Koeppen; Yibing Yan; James Larkin

doi:10.1111/pcmr.12670

Association of programmed death ligand-1 (PD-L1) expression with treatment outcomes in patients with BRAF mutation-positive melanoma treated with vemurafenib or cobimetinib combined with vemurafenib

Matthew J Wongchenko, Antoni Ribas, Brigitte Dréno, Paolo A Ascierto, Grant A McArthur, Jorge D Gallo, Isabelle A Rooney, Jessie Hsu, Hartmut Koeppen, Yibing Yan, James Larkin

Istituto Nazionale Tumori Fondazione G. Pascale

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Abstract

The prognostic significance of programmed death ligand-1 (PD-L1) on treatment outcomes in patients receiving BRAF with or without MEK inhibitors is not well understood. This retrospective exploratory analysis evaluated the association of tumour PD-L1 expression with progression-free survival (PFS) and overall survival (OS) among 210 patients in the coBRIM trial treated with cobimetinib plus vemurafenib or placebo plus vemurafenib. In the vemurafenib cohort, there was a trend of increased PFS and OS in those with PD-L1+ melanoma, with hazard ratios (HRs; PD-L1+ vs. PD-L1- ) of 0.70 (95% CI, 0.46-1.07) and 0.69 (95% CI, 0.42-1.13) for PFS and OS, respectively. However, in patients treated with cobimetinib plus vemurafenib, a similar trend was not observed with HRs (PD-L1+ versus PD-L1- ) of 1.04 (95% CI, 0.66-1.68) and 0.94 (95% CI, 0.57-1.57) for PFS and OS, respectively. The combination cobimetinib plus vemurafenib appears to overcome the poor prognosis associated with low PD-L1 expression.

Original language	English
Pages (from-to)	516-522
Number of pages	7
Journal	Pigment Cell and Melanoma Research
Volume	31
Issue number	4
DOIs	https://doi.org/10.1111/pcmr.12670
Publication status	Published - Jul 2018

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Wongchenko, M. J., Ribas, A., Dréno, B., Ascierto, P. A., McArthur, G. A., Gallo, J. D., Rooney, I. A., Hsu, J., Koeppen, H., Yan, Y., & Larkin, J. (2018). Association of programmed death ligand-1 (PD-L1) expression with treatment outcomes in patients with BRAF mutation-positive melanoma treated with vemurafenib or cobimetinib combined with vemurafenib. Pigment Cell and Melanoma Research, 31(4), 516-522. https://doi.org/10.1111/pcmr.12670

Association of programmed death ligand-1 (PD-L1) expression with treatment outcomes in patients with BRAF mutation-positive melanoma treated with vemurafenib or cobimetinib combined with vemurafenib. / Wongchenko, Matthew J; Ribas, Antoni; Dréno, Brigitte; Ascierto, Paolo A; McArthur, Grant A; Gallo, Jorge D; Rooney, Isabelle A; Hsu, Jessie; Koeppen, Hartmut; Yan, Yibing; Larkin, James.

In: Pigment Cell and Melanoma Research, Vol. 31, No. 4, 07.2018, p. 516-522.

Research output: Contribution to journal › Article › peer-review

Wongchenko, MJ, Ribas, A, Dréno, B, Ascierto, PA, McArthur, GA, Gallo, JD, Rooney, IA, Hsu, J, Koeppen, H, Yan, Y & Larkin, J 2018, 'Association of programmed death ligand-1 (PD-L1) expression with treatment outcomes in patients with BRAF mutation-positive melanoma treated with vemurafenib or cobimetinib combined with vemurafenib', Pigment Cell and Melanoma Research, vol. 31, no. 4, pp. 516-522. https://doi.org/10.1111/pcmr.12670

Wongchenko MJ, Ribas A, Dréno B, Ascierto PA, McArthur GA, Gallo JD et al. Association of programmed death ligand-1 (PD-L1) expression with treatment outcomes in patients with BRAF mutation-positive melanoma treated with vemurafenib or cobimetinib combined with vemurafenib. Pigment Cell and Melanoma Research. 2018 Jul;31(4):516-522. https://doi.org/10.1111/pcmr.12670

Wongchenko, Matthew J ; Ribas, Antoni ; Dréno, Brigitte ; Ascierto, Paolo A ; McArthur, Grant A ; Gallo, Jorge D ; Rooney, Isabelle A ; Hsu, Jessie ; Koeppen, Hartmut ; Yan, Yibing ; Larkin, James. / Association of programmed death ligand-1 (PD-L1) expression with treatment outcomes in patients with BRAF mutation-positive melanoma treated with vemurafenib or cobimetinib combined with vemurafenib. In: Pigment Cell and Melanoma Research. 2018 ; Vol. 31, No. 4. pp. 516-522.

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title = "Association of programmed death ligand-1 (PD-L1) expression with treatment outcomes in patients with BRAF mutation-positive melanoma treated with vemurafenib or cobimetinib combined with vemurafenib",

abstract = "The prognostic significance of programmed death ligand-1 (PD-L1) on treatment outcomes in patients receiving BRAF with or without MEK inhibitors is not well understood. This retrospective exploratory analysis evaluated the association of tumour PD-L1 expression with progression-free survival (PFS) and overall survival (OS) among 210 patients in the coBRIM trial treated with cobimetinib plus vemurafenib or placebo plus vemurafenib. In the vemurafenib cohort, there was a trend of increased PFS and OS in those with PD-L1+ melanoma, with hazard ratios (HRs; PD-L1+ vs. PD-L1- ) of 0.70 (95% CI, 0.46-1.07) and 0.69 (95% CI, 0.42-1.13) for PFS and OS, respectively. However, in patients treated with cobimetinib plus vemurafenib, a similar trend was not observed with HRs (PD-L1+ versus PD-L1- ) of 1.04 (95% CI, 0.66-1.68) and 0.94 (95% CI, 0.57-1.57) for PFS and OS, respectively. The combination cobimetinib plus vemurafenib appears to overcome the poor prognosis associated with low PD-L1 expression.",

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AU - Dréno, Brigitte

AU - Ascierto, Paolo A

AU - McArthur, Grant A

AU - Gallo, Jorge D

AU - Rooney, Isabelle A

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AU - Koeppen, Hartmut

AU - Yan, Yibing

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AB - The prognostic significance of programmed death ligand-1 (PD-L1) on treatment outcomes in patients receiving BRAF with or without MEK inhibitors is not well understood. This retrospective exploratory analysis evaluated the association of tumour PD-L1 expression with progression-free survival (PFS) and overall survival (OS) among 210 patients in the coBRIM trial treated with cobimetinib plus vemurafenib or placebo plus vemurafenib. In the vemurafenib cohort, there was a trend of increased PFS and OS in those with PD-L1+ melanoma, with hazard ratios (HRs; PD-L1+ vs. PD-L1- ) of 0.70 (95% CI, 0.46-1.07) and 0.69 (95% CI, 0.42-1.13) for PFS and OS, respectively. However, in patients treated with cobimetinib plus vemurafenib, a similar trend was not observed with HRs (PD-L1+ versus PD-L1- ) of 1.04 (95% CI, 0.66-1.68) and 0.94 (95% CI, 0.57-1.57) for PFS and OS, respectively. The combination cobimetinib plus vemurafenib appears to overcome the poor prognosis associated with low PD-L1 expression.

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Association of programmed death ligand-1 (PD-L1) expression with treatment outcomes in patients with BRAF mutation-positive melanoma treated with vemurafenib or cobimetinib combined with vemurafenib

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