Association of renal damage with cardiovascular diseases is independent of individual cardiovascular risk profile in hypertension: Data from the Italy-Developing Education and awareness on MicroAlbuminuria in patients with hypertensive Disease study

Sebastiano Sciarretta, Valentina Valenti, Giuliano Tocci, Roberto Pontremoli, Enrico Agabiti Rosei, Ettore Ambrosioni, Vittorio Costa, Gastone Leonetti, Achille Cesare Pessina, Bruno Trimarco, Diana Chin, Francesco Paneni, Giacomo Deferrari, Andrea Ferrucci, Massimo Volpe

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: In the past years, several risk charts have been created to increase the accuracy of cardiovascular risk stratification. The most widely used and validated algorithms do not included target organ damage as risk prediction. The aim of the present study was to evaluate whether preclinical renal damage is associated with cardiovascular diseases independently of individual risk profile assessed by risk charts. Methods: The study population was that of Italy-Developing Education and awareness on MicroAlbuminuria in patients with hypertensive Disease, a large observational study conducted on hypertensive patients in Italy. The Framingham Risk Score (FRS), Systematic COronary Risk Estimation (SCORE) and Progetto Cuore Risk Score (Progetto Cuore RS) were computed in each eligible patient. Chronic kidney disease was defined by the presence of albuminuria or by a reduction of glomerular filtration rate. Results: Study participants were categorized to have low, medium and high risk according to the tertiles of the three charts. Prevalence of total cardiovascular diseases progressively and significantly increased according to the degrees of risk assessed by the three charts, the highest prevalence being in participants with a high-risk profile (both high and medium vs. low risk

Original languageEnglish
Pages (from-to)251-258
Number of pages8
JournalJournal of Hypertension
Volume28
Issue number2
DOIs
Publication statusPublished - Feb 2010

Keywords

  • Cardiovascular risk
  • Hypertension
  • Renal damage
  • Risk charts

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Fingerprint

Dive into the research topics of 'Association of renal damage with cardiovascular diseases is independent of individual cardiovascular risk profile in hypertension: Data from the Italy-Developing Education and awareness on MicroAlbuminuria in patients with hypertensive Disease study'. Together they form a unique fingerprint.

Cite this