Association of retinitis pigmentosa,angle closure glaucoma and iridocorneal angle anomalies

G. Ruberto, G. Milano, P. E. Bianchi, F. Trimarchi, C. Danesino, C. Dellavecchia

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Abstract

Purpose: To analyze the association of Retinitis Pigmentosa(RP),Angle Closure glaucoma(Acg)and iridocorneal angle anomalies in patients suffering with RP and their relatives. Methods: 24 patients with RP from 22 families and 29 relatives were submitted to full ophthalmic examination(visual acuity,slit lamp examination of anterior segment and iridocorneal angle,fundus indirect ophthalmoscopy, I.O.P.).full field electroretinography.Results: A diagnosis of RP was established by funduscopy and/or rod or rod and cones reduced response in 26 subjects(24 index cases and two asymptomatic relatives).Acg was observed in 7.6%(2 cases) of RP patients and in 14.8%of their relatives.Different degree of iridocorneal angle anomalies were observed in 15.3%(4 cases)of RP patients and in 22.2%of their relatives.No mutations were observed in the rodopsin gene in the two families studied.Conclusions: Our results confirmed association of RP and ACG with a frequency higher than the one reported by Badeeb and coil. An unespected hig frequency of Acg or iridocorneal angle anomalies was also found among patient's relatives.

Original languageEnglish
JournalInvestigative Ophthalmology and Visual Science
Volume37
Issue number3
Publication statusPublished - Feb 15 1996

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Angle Closure Glaucoma
Retinitis Pigmentosa
Electroretinography
Ophthalmoscopy
Vertebrate Photoreceptor Cells
Visual Acuity
Mutation

ASJC Scopus subject areas

  • Ophthalmology

Cite this

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title = "Association of retinitis pigmentosa,angle closure glaucoma and iridocorneal angle anomalies",
abstract = "Purpose: To analyze the association of Retinitis Pigmentosa(RP),Angle Closure glaucoma(Acg)and iridocorneal angle anomalies in patients suffering with RP and their relatives. Methods: 24 patients with RP from 22 families and 29 relatives were submitted to full ophthalmic examination(visual acuity,slit lamp examination of anterior segment and iridocorneal angle,fundus indirect ophthalmoscopy, I.O.P.).full field electroretinography.Results: A diagnosis of RP was established by funduscopy and/or rod or rod and cones reduced response in 26 subjects(24 index cases and two asymptomatic relatives).Acg was observed in 7.6{\%}(2 cases) of RP patients and in 14.8{\%}of their relatives.Different degree of iridocorneal angle anomalies were observed in 15.3{\%}(4 cases)of RP patients and in 22.2{\%}of their relatives.No mutations were observed in the rodopsin gene in the two families studied.Conclusions: Our results confirmed association of RP and ACG with a frequency higher than the one reported by Badeeb and coil. An unespected hig frequency of Acg or iridocorneal angle anomalies was also found among patient's relatives.",
author = "G. Ruberto and G. Milano and Bianchi, {P. E.} and F. Trimarchi and C. Danesino and C. Dellavecchia",
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T1 - Association of retinitis pigmentosa,angle closure glaucoma and iridocorneal angle anomalies

AU - Ruberto, G.

AU - Milano, G.

AU - Bianchi, P. E.

AU - Trimarchi, F.

AU - Danesino, C.

AU - Dellavecchia, C.

PY - 1996/2/15

Y1 - 1996/2/15

N2 - Purpose: To analyze the association of Retinitis Pigmentosa(RP),Angle Closure glaucoma(Acg)and iridocorneal angle anomalies in patients suffering with RP and their relatives. Methods: 24 patients with RP from 22 families and 29 relatives were submitted to full ophthalmic examination(visual acuity,slit lamp examination of anterior segment and iridocorneal angle,fundus indirect ophthalmoscopy, I.O.P.).full field electroretinography.Results: A diagnosis of RP was established by funduscopy and/or rod or rod and cones reduced response in 26 subjects(24 index cases and two asymptomatic relatives).Acg was observed in 7.6%(2 cases) of RP patients and in 14.8%of their relatives.Different degree of iridocorneal angle anomalies were observed in 15.3%(4 cases)of RP patients and in 22.2%of their relatives.No mutations were observed in the rodopsin gene in the two families studied.Conclusions: Our results confirmed association of RP and ACG with a frequency higher than the one reported by Badeeb and coil. An unespected hig frequency of Acg or iridocorneal angle anomalies was also found among patient's relatives.

AB - Purpose: To analyze the association of Retinitis Pigmentosa(RP),Angle Closure glaucoma(Acg)and iridocorneal angle anomalies in patients suffering with RP and their relatives. Methods: 24 patients with RP from 22 families and 29 relatives were submitted to full ophthalmic examination(visual acuity,slit lamp examination of anterior segment and iridocorneal angle,fundus indirect ophthalmoscopy, I.O.P.).full field electroretinography.Results: A diagnosis of RP was established by funduscopy and/or rod or rod and cones reduced response in 26 subjects(24 index cases and two asymptomatic relatives).Acg was observed in 7.6%(2 cases) of RP patients and in 14.8%of their relatives.Different degree of iridocorneal angle anomalies were observed in 15.3%(4 cases)of RP patients and in 22.2%of their relatives.No mutations were observed in the rodopsin gene in the two families studied.Conclusions: Our results confirmed association of RP and ACG with a frequency higher than the one reported by Badeeb and coil. An unespected hig frequency of Acg or iridocorneal angle anomalies was also found among patient's relatives.

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