Purpose: To analyze the association of Retinitis Pigmentosa(RP),Angle Closure glaucoma(Acg)and iridocorneal angle anomalies in patients suffering with RP and their relatives. Methods: 24 patients with RP from 22 families and 29 relatives were submitted to full ophthalmic examination(visual acuity,slit lamp examination of anterior segment and iridocorneal angle,fundus indirect ophthalmoscopy, I.O.P.).full field electroretinography.Results: A diagnosis of RP was established by funduscopy and/or rod or rod and cones reduced response in 26 subjects(24 index cases and two asymptomatic relatives).Acg was observed in 7.6%(2 cases) of RP patients and in 14.8%of their relatives.Different degree of iridocorneal angle anomalies were observed in 15.3%(4 cases)of RP patients and in 22.2%of their relatives.No mutations were observed in the rodopsin gene in the two families studied.Conclusions: Our results confirmed association of RP and ACG with a frequency higher than the one reported by Badeeb and coil. An unespected hig frequency of Acg or iridocorneal angle anomalies was also found among patient's relatives.
|Journal||Investigative Ophthalmology and Visual Science|
|Publication status||Published - Feb 15 1996|
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