Abstract
Few data are available on the association between serum lipids and insulin secretion (ISEC) in children. We evaluated the association of triglycerides (TG), HDL cholesterol (HDL-C) and LDL cholesterol (LDL-C) with ISEC in 1150 non-diabetic obese children and adolescents using multivariable robust median regression. The following models were employed: (1) IGI or incAUCR as the ISEC response variable; (2) QUICKI, OGIS, the Stumvoll index or the Matsuda insulin sensitivity index as the insulin sensitivity (ISEN) predictor; (3) TG, HDL-C and LDL-C as the predictors of interest; (4) 120-min glucose, age, sex and body mass index as confounders. LDL-C and TG were not associated with ISEC in any model. In three out of four IGI models, an increase of 1 interquartile range (IQR) of HDL-C was associated with a decrease of median incAUCR ranging from −9 (robust 95% CI −17 to −2) to −8 (−14 to −1) pmol/mmol. In two out of four incAUCR models, an increase of 1 IQR of HDL-C was associated with a decrease of median IGI ranging from −8 (−15 to −1) to −7 (−11 to −2) pmol/mmol. TG and LDL-C are not associated and HDL-C is inversely associated with ISEC in obese children and adolescents.
| Original language | English |
|---|---|
| Pages (from-to) | 1318-1323 |
| Number of pages | 6 |
| Journal | Endocrine Connections |
| Volume | 8 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Jan 1 2019 |
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Keywords
- Adolescents
- Children
- Cholesterol
- Insulin secretion
- Obesity
- Triglycerides
ASJC Scopus subject areas
- Internal Medicine
- Endocrinology, Diabetes and Metabolism
- Endocrinology
Cite this
Association of serum lipids with β-cell function in obese children and adolescents. / Bedogni, Giorgio; Mari, Andrea; De Col, Alessandra; Tamini, Sofia; Gastaldelli, Amalia; Sartorio, Alessandro.
In: Endocrine Connections, Vol. 8, No. 10, 01.01.2019, p. 1318-1323.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association of serum lipids with β-cell function in obese children and adolescents
AU - Bedogni, Giorgio
AU - Mari, Andrea
AU - De Col, Alessandra
AU - Tamini, Sofia
AU - Gastaldelli, Amalia
AU - Sartorio, Alessandro
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Few data are available on the association between serum lipids and insulin secretion (ISEC) in children. We evaluated the association of triglycerides (TG), HDL cholesterol (HDL-C) and LDL cholesterol (LDL-C) with ISEC in 1150 non-diabetic obese children and adolescents using multivariable robust median regression. The following models were employed: (1) IGI or incAUCR as the ISEC response variable; (2) QUICKI, OGIS, the Stumvoll index or the Matsuda insulin sensitivity index as the insulin sensitivity (ISEN) predictor; (3) TG, HDL-C and LDL-C as the predictors of interest; (4) 120-min glucose, age, sex and body mass index as confounders. LDL-C and TG were not associated with ISEC in any model. In three out of four IGI models, an increase of 1 interquartile range (IQR) of HDL-C was associated with a decrease of median incAUCR ranging from −9 (robust 95% CI −17 to −2) to −8 (−14 to −1) pmol/mmol. In two out of four incAUCR models, an increase of 1 IQR of HDL-C was associated with a decrease of median IGI ranging from −8 (−15 to −1) to −7 (−11 to −2) pmol/mmol. TG and LDL-C are not associated and HDL-C is inversely associated with ISEC in obese children and adolescents.
AB - Few data are available on the association between serum lipids and insulin secretion (ISEC) in children. We evaluated the association of triglycerides (TG), HDL cholesterol (HDL-C) and LDL cholesterol (LDL-C) with ISEC in 1150 non-diabetic obese children and adolescents using multivariable robust median regression. The following models were employed: (1) IGI or incAUCR as the ISEC response variable; (2) QUICKI, OGIS, the Stumvoll index or the Matsuda insulin sensitivity index as the insulin sensitivity (ISEN) predictor; (3) TG, HDL-C and LDL-C as the predictors of interest; (4) 120-min glucose, age, sex and body mass index as confounders. LDL-C and TG were not associated with ISEC in any model. In three out of four IGI models, an increase of 1 interquartile range (IQR) of HDL-C was associated with a decrease of median incAUCR ranging from −9 (robust 95% CI −17 to −2) to −8 (−14 to −1) pmol/mmol. In two out of four incAUCR models, an increase of 1 IQR of HDL-C was associated with a decrease of median IGI ranging from −8 (−15 to −1) to −7 (−11 to −2) pmol/mmol. TG and LDL-C are not associated and HDL-C is inversely associated with ISEC in obese children and adolescents.
KW - Adolescents
KW - Children
KW - Cholesterol
KW - Insulin secretion
KW - Obesity
KW - Triglycerides
UR - http://www.scopus.com/inward/record.url?scp=85073539254&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85073539254&partnerID=8YFLogxK
U2 - 10.1530/EC-19-0333
DO - 10.1530/EC-19-0333
M3 - Article
AN - SCOPUS:85073539254
VL - 8
SP - 1318
EP - 1323
JO - Endocrine Connections
JF - Endocrine Connections
SN - 2049-3614
IS - 10
ER -