TY - JOUR
T1 - Association of short-term memory with a variant within DYX1C1 in developmental dyslexia
AU - Marino, C.
AU - Citterio, A.
AU - Giorda, R.
AU - Facoetti, A.
AU - Menozzi, G.
AU - Vanzin, L.
AU - Lorusso, M. L.
AU - Nobile, M.
AU - Molteni, M.
PY - 2007/10
Y1 - 2007/10
N2 - A substantial genetic contribution in the etiology of developmental dyslexia (DD) has been well documented with independent groups reporting a susceptibility locus on chromosome 15q. After the identification of the DYX1C1 gene as a potential candidate for DD, several independent association studies reported controversial results. We performed a family-based association study to determine whether the DYX1C1 single nucleotide polymorphisms (SNPs) that have been associated with DD before, that is SNPs '-3GA' and '1249GT', influence a broader phenotypic definition of DD. A significant linkage disequilibrium was observed with 'Single Letter Backward Span' (SLBS) in both single-marker and haplotype analyses. These results provide further support to the association between DD and DYX1C1 and it suggests that the linkage disequilibrium with DYX1C1 is more saliently explained in Italian dyslexics by short-term memory, as measured by 'SLBS', than by the categorical diagnosis of DD or other related phenotypes.
AB - A substantial genetic contribution in the etiology of developmental dyslexia (DD) has been well documented with independent groups reporting a susceptibility locus on chromosome 15q. After the identification of the DYX1C1 gene as a potential candidate for DD, several independent association studies reported controversial results. We performed a family-based association study to determine whether the DYX1C1 single nucleotide polymorphisms (SNPs) that have been associated with DD before, that is SNPs '-3GA' and '1249GT', influence a broader phenotypic definition of DD. A significant linkage disequilibrium was observed with 'Single Letter Backward Span' (SLBS) in both single-marker and haplotype analyses. These results provide further support to the association between DD and DYX1C1 and it suggests that the linkage disequilibrium with DYX1C1 is more saliently explained in Italian dyslexics by short-term memory, as measured by 'SLBS', than by the categorical diagnosis of DD or other related phenotypes.
KW - Developmental dyslexia
KW - DYX1C1
KW - Genetic association
KW - Short-term memory
UR - http://www.scopus.com/inward/record.url?scp=34748875368&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34748875368&partnerID=8YFLogxK
U2 - 10.1111/j.1601-183X.2006.00291.x
DO - 10.1111/j.1601-183X.2006.00291.x
M3 - Article
C2 - 17309662
AN - SCOPUS:34748875368
VL - 6
SP - 640
EP - 646
JO - Genes, Brain and Behavior
JF - Genes, Brain and Behavior
SN - 1601-1848
IS - 7
ER -