Association of short-term memory with a variant within DYX1C1 in developmental dyslexia

C. Marino, A. Citterio, R. Giorda, A. Facoetti, G. Menozzi, L. Vanzin, M. L. Lorusso, M. Nobile, M. Molteni

Research output: Contribution to journalArticle

Abstract

A substantial genetic contribution in the etiology of developmental dyslexia (DD) has been well documented with independent groups reporting a susceptibility locus on chromosome 15q. After the identification of the DYX1C1 gene as a potential candidate for DD, several independent association studies reported controversial results. We performed a family-based association study to determine whether the DYX1C1 single nucleotide polymorphisms (SNPs) that have been associated with DD before, that is SNPs '-3GA' and '1249GT', influence a broader phenotypic definition of DD. A significant linkage disequilibrium was observed with 'Single Letter Backward Span' (SLBS) in both single-marker and haplotype analyses. These results provide further support to the association between DD and DYX1C1 and it suggests that the linkage disequilibrium with DYX1C1 is more saliently explained in Italian dyslexics by short-term memory, as measured by 'SLBS', than by the categorical diagnosis of DD or other related phenotypes.

Original languageEnglish
Pages (from-to)640-646
Number of pages7
JournalGenes, Brain and Behavior
Volume6
Issue number7
DOIs
Publication statusPublished - Oct 2007

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Keywords

  • Developmental dyslexia
  • DYX1C1
  • Genetic association
  • Short-term memory

ASJC Scopus subject areas

  • Genetics
  • Neuroscience(all)

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