Association of systemic lupus erythematosus with peripheral arterial disease: A meta-analysis of literature studies

Francesco Forte, Alessio Buonaiuto, Ilenia Calcaterra, Gabriella Iannuzzo, Pasquale Ambrosino, Matteo Nicola Dario Di Minno

Research output: Contribution to journalReview articlepeer-review


Objective. SLE patients have an increased cardiovascular morbidity and mortality. Contrasting data are available about the association between peripheral arterial disease (PAD) and SLE. We aimed to perform a meta-analysis of studies evaluating the association between SLE and PAD. Methods. Studies were systematically searched in the PubMed, Web of Science, Scopus and EMBASE databases according to preferred reporting items for systematic reviews and meta-analyses guidelines. Results. Eight studies reporting on 263 258 SLE patients and 768 487 controls showed that the prevalence of PAD was 15.8% (95% CI: 10.5%, 23.2%) in SLE patients and 3.9% (95% CI: 1.8%, 7.9%) in controls with a corresponding odds ratio of 4.1 (95% CI: 1.5, 11.6; P <0.001). In addition, five studies reporting on ankle-brachial index showed significantly lower values in 280 SLE patients as compared with 201 controls (mean difference: 0.018; 95% CI: 0.034, 0.001; P ¼0.033). Meta-regression models showed that age, hypertension and diabetes were inversely associated with the difference in the prevalence of PAD between SLE patients and non-SLE controls, whereas no effect for all the other clinical and demographic variables on the evaluated outcome was found. Conclusion. SLE patients exhibit an increased prevalence of PAD and lower ankle-brachial index values as compared with non-SLE controls. This should be considered when planning prevention, interventional and rehabilitation strategies for these chronic patients with functional disability and poor long-term outcomes.

Original languageEnglish
Pages (from-to)3181-3192
Number of pages12
Issue number11
Publication statusPublished - Nov 1 2020


  • Ankle-brachial index
  • Cardiovascular diseases
  • Chronic disease
  • Disability
  • Outcome
  • Peripheral arterial disease
  • SLE

ASJC Scopus subject areas

  • Rheumatology


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