Association of the α-adducin locus with essential hypertension

G. Casari, C. Barlassina, D. Cusi, L. Zagato, R. Muirhead, M. Righetti, P. Nembri, K. Amar, M. Gatti, F. Macciardi, G. Binelli, G. Bianchi

Research output: Contribution to journalArticle

Abstract

Previous studies on genetic rat hypertension have shown that polymorphism within the α-adducin gene may regulate blood pressure. Adducin is a cytoskeletal protein that may be involved in cellular signal transduction and interacts with other membrane-skeleton proteins that affect ion transport across the cell membrane. There is a high homology between rat and human adducin and pathophysiological similarities between the Milan hypertensive rat strain and a subgroup of patients with essential hypertension. Thus, we designed a case-control study to test the possible association between the α-adducin locus and hypertension. One hundred ninety primary hypertensive patients were compared with 126 control subjects. All subjects were white and unrelated. Four multiallelic markers surrounding the α-adducin locus located in 4p16.3 were selected: D4S125 and D4S95 mapping at 680 and 20 kb centromeric, and D4S43 and D4S228/E24 mapping at 660 and 2500 kb telomeric. Alleles for each marker were pooled into groups. Comparisons between control subjects and hypertensive patients were carried out by testing the allele- disease association relative to the marker genotype. The maximal association occurred for D4S95 (χ1/2 13.33), which maps closest to α-adducin. These data suggest that a polymorphism within the α-adducin gene may affect blood pressure in humans.

Original languageEnglish
Pages (from-to)320-326
Number of pages7
JournalHypertension
Volume25
Issue number3
Publication statusPublished - 1995

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Keywords

  • case-control studies
  • cytoskeleton
  • genes
  • hypertension, essential
  • polymorphism (genetics)

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Casari, G., Barlassina, C., Cusi, D., Zagato, L., Muirhead, R., Righetti, M., Nembri, P., Amar, K., Gatti, M., Macciardi, F., Binelli, G., & Bianchi, G. (1995). Association of the α-adducin locus with essential hypertension. Hypertension, 25(3), 320-326.