TY - JOUR
T1 - Association of the C(- 1019)G 5-HT1A promoter polymorphism with exposure to stressors preceding hospitalization for bipolar depression
AU - Benedetti, Francesco
AU - Radaelli, Daniele
AU - Poletti, Sara
AU - Locatelli, Clara
AU - Dallaspezia, Sara
AU - Lorenzi, Cristina
AU - Pirovano, Adele
AU - Colombo, Cristina
AU - Smeraldi, Enrico
PY - 2011/7
Y1 - 2011/7
N2 - Rationale: In animals, a higher density of 5-HT1A receptors has been associated with increased behavioral despair after stress. In humans, the G variant of the C(- 1019)G 5-HT1A receptor promoter gene polymorphism (rs6295) has been associated with higher expression of 5-HT1A receptors, increased depression, and lower stress preceding completed suicide. Objectives: We studied the association of rs6295 with the amount of stress in early life and preceding hospitalization for a major depressive episode in course of bipolar disorder. Materials and methods: In 74 consecutively admitted inpatients, early life and recent stressors were rated on the Social Readjustment Rating Scale and on the Risky Family Questionnaire. Results: Homozygote carriers of the rs6295 G variant reported less stressful events before current hospitalization for bipolar depression, but not in early life. The G variant was also associated with a higher overall medication load in naturalistic settings before hospitalization. Conclusions: This is the first study that associated 5-HT1A receptor promoter gene variants with stressors preceding the need of hospitalization for bipolar depression. Our findings support the hypothesis that genetic factors affecting serotonergic neurotransmission might contribute to shape the individual resilience to the depressogenic effects of stress in clinical settings.
AB - Rationale: In animals, a higher density of 5-HT1A receptors has been associated with increased behavioral despair after stress. In humans, the G variant of the C(- 1019)G 5-HT1A receptor promoter gene polymorphism (rs6295) has been associated with higher expression of 5-HT1A receptors, increased depression, and lower stress preceding completed suicide. Objectives: We studied the association of rs6295 with the amount of stress in early life and preceding hospitalization for a major depressive episode in course of bipolar disorder. Materials and methods: In 74 consecutively admitted inpatients, early life and recent stressors were rated on the Social Readjustment Rating Scale and on the Risky Family Questionnaire. Results: Homozygote carriers of the rs6295 G variant reported less stressful events before current hospitalization for bipolar depression, but not in early life. The G variant was also associated with a higher overall medication load in naturalistic settings before hospitalization. Conclusions: This is the first study that associated 5-HT1A receptor promoter gene variants with stressors preceding the need of hospitalization for bipolar depression. Our findings support the hypothesis that genetic factors affecting serotonergic neurotransmission might contribute to shape the individual resilience to the depressogenic effects of stress in clinical settings.
KW - 5-HT1A
KW - Bipolar disorder
KW - Depression
KW - Genetics
KW - Serotonin
KW - Stress
KW - Suicide
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U2 - 10.1016/j.jad.2011.02.024
DO - 10.1016/j.jad.2011.02.024
M3 - Article
C2 - 21397953
AN - SCOPUS:79958084955
VL - 132
SP - 297
EP - 300
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
SN - 0165-0327
IS - 1-2
ER -