Association of the CBLB gene with multiple sclerosis

New evidence from a replication study in an Italian population

Lucia Corrado, Laura Bergamaschi, Nadia Barizzone, Maria Edvige Fasano, Franca R. Guerini, Marco Salvetti, Daniela Galimberti, Maria Donata Benedetti, Maurizio Leone, Sandra D'Alfonso

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: The T allele of rs9657904 within the CBLB gene was recently found to be significantly associated with multiple sclerosis (MS) in a genome-wide association study in Sardinia. Objective: To replicate this association in an independent population with a different genetic background. Methods: The rs9657904 variant was typed in a sample of 1435 cases and 1466 controls from the Italian mainland. Results: It was found that in this sample also, the common allele T of rs9657904 is significantly positively associated (one-tailed p = 7.35×10-5) and with a comparable effect size with MS (OR=1.31, 95% CI 1.14 to 1.52). Conclusion: These data provide further evidence of the association of MS disease with variation within CBLB.

Original languageEnglish
Pages (from-to)210-211
Number of pages2
JournalJournal of Medical Genetics
Volume48
Issue number3
DOIs
Publication statusPublished - Mar 2011

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Multiple Sclerosis
Alleles
Population
Genes
Genome-Wide Association Study
Italy
Genetic Background

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Association of the CBLB gene with multiple sclerosis : New evidence from a replication study in an Italian population. / Corrado, Lucia; Bergamaschi, Laura; Barizzone, Nadia; Fasano, Maria Edvige; Guerini, Franca R.; Salvetti, Marco; Galimberti, Daniela; Benedetti, Maria Donata; Leone, Maurizio; D'Alfonso, Sandra.

In: Journal of Medical Genetics, Vol. 48, No. 3, 03.2011, p. 210-211.

Research output: Contribution to journalArticle

Corrado, Lucia ; Bergamaschi, Laura ; Barizzone, Nadia ; Fasano, Maria Edvige ; Guerini, Franca R. ; Salvetti, Marco ; Galimberti, Daniela ; Benedetti, Maria Donata ; Leone, Maurizio ; D'Alfonso, Sandra. / Association of the CBLB gene with multiple sclerosis : New evidence from a replication study in an Italian population. In: Journal of Medical Genetics. 2011 ; Vol. 48, No. 3. pp. 210-211.
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AU - Guerini, Franca R.

AU - Salvetti, Marco

AU - Galimberti, Daniela

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