Association of the HLA-G 3′UTR polymorphisms with colorectal cancer in Italy: A first insight

Marica Garziera, Eulalia Catamo, Sergio Crovella, M. Montico, Erika Cecchin, Sara Lonardi, E. Mini, Stefania Nobili, L. Romanato, Giuseppe Toffoli

Research output: Contribution to journalArticlepeer-review

Abstract

This study aimed to explore functional and regulatory polymorphisms and haplotypes at the HLA-G 3′UTR region in colorectal cancer development. The presence of nonpolymorphic variants was also evaluated. Three-hundred and eight patients with colorectal cancer and 294 healthy controls were analysed at the germinal level. We found an association with increased risk of colorectal cancer for +2960 14-bp INDEL, +3196 C>G SNPs and UTR-2 haplotype, and a 'protective' role for +3003 T>C, +3010 C>G polymorphisms and UTR-4 haplotype. We detected in 3 distinct patients, a novel nucleotide change (+3037 C>A) and 2 already described rare variants, +3032 G/C (EUR MAF=0.1%) and +3092G/T (EUR MAF=0%). This is the first study showing associations between different polymorphisms in the HLA-G 3′UTR and colorectal cancer susceptibility.

Original languageEnglish
Pages (from-to)32-39
Number of pages8
JournalInternational Journal of Immunogenetics
Volume43
Issue number1
DOIs
Publication statusPublished - Feb 1 2016

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Immunology
  • Genetics(clinical)

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