Association of the HLA-G 3′UTR polymorphisms with colorectal cancer in Italy: A first insight

M. Garziera; E. Catamo; S. Crovella; M. Montico; E. Cecchin; S. Lonardi; E. Mini; S. Nobili; L. Romanato; G. Toffoli

doi:10.1111/iji.12243

Association of the HLA-G 3′UTR polymorphisms with colorectal cancer in Italy: A first insight

M. Garziera, E. Catamo, S. Crovella, M. Montico, E. Cecchin, S. Lonardi, E. Mini, S. Nobili, L. Romanato, G. Toffoli

Research output: Contribution to journal › Article › peer-review

Abstract

This study aimed to explore functional and regulatory polymorphisms and haplotypes at the HLA-G 3′UTR region in colorectal cancer development. The presence of nonpolymorphic variants was also evaluated. Three-hundred and eight patients with colorectal cancer and 294 healthy controls were analysed at the germinal level. We found an association with increased risk of colorectal cancer for +2960 14-bp INDEL, +3196 C>G SNPs and UTR-2 haplotype, and a 'protective' role for +3003 T>C, +3010 C>G polymorphisms and UTR-4 haplotype. We detected in 3 distinct patients, a novel nucleotide change (+3037 C>A) and 2 already described rare variants, +3032 G/C (EUR MAF=0.1%) and +3092G/T (EUR MAF=0%). This is the first study showing associations between different polymorphisms in the HLA-G 3′UTR and colorectal cancer susceptibility.

Original language	English
Pages (from-to)	32-39
Number of pages	8
Journal	International Journal of Immunogenetics
Volume	43
Issue number	1
DOIs	https://doi.org/10.1111/iji.12243
Publication status	Published - Feb 1 2016

ASJC Scopus subject areas

Genetics
Molecular Biology
Immunology
Genetics(clinical)

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Association of the HLA-G 3′UTR polymorphisms with colorectal cancer in Italy : A first insight. / Garziera, M.; Catamo, E.; Crovella, S.; Montico, M.; Cecchin, E.; Lonardi, S.; Mini, E.; Nobili, S.; Romanato, L.; Toffoli, G.

In: International Journal of Immunogenetics, Vol. 43, No. 1, 01.02.2016, p. 32-39.

Research output: Contribution to journal › Article › peer-review

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abstract = "This study aimed to explore functional and regulatory polymorphisms and haplotypes at the HLA-G 3′UTR region in colorectal cancer development. The presence of nonpolymorphic variants was also evaluated. Three-hundred and eight patients with colorectal cancer and 294 healthy controls were analysed at the germinal level. We found an association with increased risk of colorectal cancer for +2960 14-bp INDEL, +3196 C>G SNPs and UTR-2 haplotype, and a 'protective' role for +3003 T>C, +3010 C>G polymorphisms and UTR-4 haplotype. We detected in 3 distinct patients, a novel nucleotide change (+3037 C>A) and 2 already described rare variants, +3032 G/C (EUR MAF=0.1%) and +3092G/T (EUR MAF=0%). This is the first study showing associations between different polymorphisms in the HLA-G 3′UTR and colorectal cancer susceptibility.",

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AU - Cecchin, E.

AU - Lonardi, S.

AU - Mini, E.

AU - Nobili, S.

AU - Romanato, L.

AU - Toffoli, G.

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Association of the HLA-G 3′UTR polymorphisms with colorectal cancer in Italy: A first insight

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