Association of the hOGG1 Ser326Cys polymorphism with sporadic amyotrophic lateral sclerosis

Fabio Coppedè, Michelangelo Mancuso, Annalisa Lo Gerfo, Cecilia Carlesi, Selina Piazza, Anna Rocchi, Lucia Petrozzi, Claudia Nesti, Dario Micheli, Andrea Bacci, Lucia Migliore, Luigi Murri, Gabriele Siciliano

Research output: Contribution to journalArticle

Abstract

Amyotropic lateral sclerosis (ALS) is a fatal and progressive neurodegenerative disease causing the loss of motoneurons of the brain and the spinal cord. The etiology of ALS is still uncertain, but males are at increased risk for the disease than females. Several studies have suggested that motoneurons in ALS might be subjected to the double insult of increased DNA oxidative damage and deficiencies in DNA repair systems. Particularly, increased levels of 8-oxoguanine and impairments of the DNA base excision repair system have been observed in neurons of ALS patients. There is evidence that the Ser326Cys polymorphism of the human 8-oxoguanine DNA glycosylase 1 (hOGG1) gene is associated with a reduced DNA repair activity. To evaluate the role of the hOGG1 Ser326Cys polymorphism in sporadic ALS (sALS), we screened 136 patients and 129 matched controls. In the total population, we observed association between both the Cys326 allele (p = 0.02) and the combined Ser326Cys + Cys326Cys genotype (OR = 1.65, 95% CI = 1.06-2.88) and increased risk of disease. After stratification by gender, the Cys326 allele (p = 0.01), both the Ser326Cys genotype (OR = 2.14, 95% CI = 1.09-4.19) and the combined Ser326Cys + Cys326Cys genotype (OR = 2.15, 95% CI = 1.16-4.01) were associated with sALS risk only in males. No significant association between the Ser326Cys polymorphism and disease phenotype, including age and site of onset and disease progression, was observed. Present results suggest a possible involvement of the hOGG1 Ser326Cys polymorphism in sALS pathogenesis.

Original languageEnglish
Pages (from-to)163-168
Number of pages6
JournalNeuroscience Letters
Volume420
Issue number2
DOIs
Publication statusPublished - Jun 13 2007

Keywords

  • Amyotrophic lateral sclerosis
  • Base excision repair (BER)
  • DNA repair
  • hOGG1 Ser326Cys polymorphism
  • Oxidative damage

ASJC Scopus subject areas

  • Neuroscience(all)

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    Coppedè, F., Mancuso, M., Lo Gerfo, A., Carlesi, C., Piazza, S., Rocchi, A., Petrozzi, L., Nesti, C., Micheli, D., Bacci, A., Migliore, L., Murri, L., & Siciliano, G. (2007). Association of the hOGG1 Ser326Cys polymorphism with sporadic amyotrophic lateral sclerosis. Neuroscience Letters, 420(2), 163-168. https://doi.org/10.1016/j.neulet.2007.04.067