Association of the human adiponectin gene and insulin resistance

Emanuela Filippi, Federica Sentinelli, Vincenzo Trischitta, Stefano Romeo, Marcello Arca, Frida Leonetti, Umberto Di Mario, Marco Giorgio Baroni

Research output: Contribution to journalArticlepeer-review

Abstract

Adiponectin is an adipocyte-secreted protein that modulates insulin sensitivity and whose low circulating concentration is associated with insulin resistance. In the present study, we analysed the association between two single-nucleoticle polymorphisms (SNPs) in the adiponectin gene and insulin resistance in 253 nondiabetic subjects. In addition, we investigated whether this association is modulated by body mass index (BMI) levels. The SNPs + 45T>G and +276G>T in the human adiponectin gene were detected in real-time PCR with LightCycler. No association was found with the + 45T>G SNP. The +276G> T SNP was associated with higher BMI (PIR (P2. In both subgroups, subjects carrying the +276G>T SNP had higher HOMAIR; however, the difference was highly significant among leaner (P2, the relative risk of insulin resistance was 9.7 (CI: 1.32-87.7, P T SNP had significantly (P<0.05) lower mean serum adiponectin levels (25.7 ng/ml) compared to noncarriers (37.0 ng/ml), suggesting a possible influence of the +276G>T SNP on adiponectin levels. In summary, we observed an association between the +276G>T SNP in the adiponectin gene and insulin resistance. In particular, among leaner individuals, the adiponectin gene appears to determine an increased risk to develop insulin resistance.

Original languageEnglish
Pages (from-to)199-205
Number of pages7
JournalEuropean Journal of Human Genetics
Volume12
Issue number3
DOIs
Publication statusPublished - Mar 2004

Keywords

  • Adiponectin gene
  • BMI (body mass index)
  • Insulin resistance
  • Real-time PCR
  • Single-nucleotide polymorphisms (SNPs)

ASJC Scopus subject areas

  • Genetics(clinical)

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