Association of thyroid dysfunction with vitamin B12, folate and plasma homocysteine levels in the elderly: A population-based study in Sicily

Giuseppe Stella, Rosario Sebastiano Spada, Santa Calabrese, Paolo Bosco, Guido Anello, Rosa Maria Guéant-Rodriguez, Antonino Romano, Lahoucine Benamghar, Caterina Proto, Antonino Castellano, Adrian Fajardo, Lina Lipari, Salvatore Sirna, Jean Louis Guéant

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Association of thyroid dysfunction with plasma homocysteine levels and vitamin B12 has previously been reported. We evaluated these associations in the elderly in San Teodoro, a mountainous village of Sicily. Methods: Subjects (n=279) aged 60-85 years (119 males and 160 females) were examined using self-reported signs, clinical examination and laboratory tests. Results: Hypothyroidism and/or goiter were two characteristics that were not associated with a significant change in homocysteine when compared with euthyroidism and the absence of goiter. Vitamin B12 was significantly higher in subjects in the first quartile of the thyroid-stimulating hormone distribution, compared with those in the fourth quartile (371±207 vs. 297±196 pmol/L, p=0.0121). Homocysteine was significantly higher in the first quartile of the free tri-iodothyronine distribution compared to the third quartile (18.0±5.7 vs. 16.0±6.2 μmol/L, p=0.0130) and was correlated with log tri-iodothyronine in euthyroid subjects (p=0.0254). In multivariate analysis, homocysteine was associated with vitamin B12 (p=0.0014), folate (p

Original languageEnglish
Pages (from-to)143-147
Number of pages5
JournalClinical Chemistry and Laboratory Medicine
Volume45
Issue number2
DOIs
Publication statusPublished - Feb 1 2007

Keywords

  • Folate
  • Homocysteine
  • Thyroid dysfunction
  • Vitamin B

ASJC Scopus subject areas

  • Clinical Biochemistry

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